TY - JOUR
T1 - Influence of metabolism on epigenetics and disease
AU - Kaelin, William G.
AU - McKnight, Steven L.
PY - 2013/3/28
Y1 - 2013/3/28
N2 - Chemical modifications of histones and DNA, such as histone methylation, histone acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of the enzymes that add or remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metabolism. This knowledge provides a conceptual foundation for understanding how mutations in the metabolic enzymes SDH, FH, and IDH can result in cancer and, more broadly, for how alterations in metabolism and nutrition might contribute to disease. Here, we review literature pertinent to hypothetical connections between metabolic and epigenetic states in eukaryotic cells.
AB - Chemical modifications of histones and DNA, such as histone methylation, histone acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of the enzymes that add or remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metabolism. This knowledge provides a conceptual foundation for understanding how mutations in the metabolic enzymes SDH, FH, and IDH can result in cancer and, more broadly, for how alterations in metabolism and nutrition might contribute to disease. Here, we review literature pertinent to hypothetical connections between metabolic and epigenetic states in eukaryotic cells.
UR - http://www.scopus.com/inward/record.url?scp=84875755814&partnerID=8YFLogxK
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U2 - 10.1016/j.cell.2013.03.004
DO - 10.1016/j.cell.2013.03.004
M3 - Review article
C2 - 23540690
AN - SCOPUS:84875755814
SN - 0092-8674
VL - 153
SP - 56
EP - 69
JO - Cell
JF - Cell
IS - 1
ER -