@article{c35d2aea1a3d487785251ff37d80df4d,
title = "Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins",
abstract = "Objectives: The aim of this study was to investigate the impact of BMI on late gadolinium enhancement (LGE) of the coronary artery wall in identical monozygous twins discordant for BMI. Coronary LGE represents a useful parameter for the detection and quantification of atherosclerotic coronary vessel wall disease. Methods: Thirteen monozygote female twin pairs (n = 26) with significantly different BMIs (>1.6 kg/m2) were recruited out of >10,000 twin pairs (TwinsUK Registry). A coronary 3D-T2prep-TFE MR angiogram and 3D-IR-TFE vessel wall scan were performed prior to and following the administration of 0.2 mmol/kg of Gd-DTPA on a 1.5 T MR scanner. The number of enhancing coronary segments and contrast to noise ratios (CNRs) of the coronary wall were quantified. Results: An increase in BMI was associated with an increased number of enhancing coronary segments (5.3 ± 1.5 vs. 3.5 ± 1.6, p < 0.0001) and increased coronary wall enhancement (6.1 ± 1.1 vs. 4.8 ± 0.9, p = 0.0027) compared to matched twins with lower BMI. Conclusions: This study in monozygous twins indicates that acquired factors predisposing to obesity, including lifestyle and environmental factors, result in increased LGE of the coronary arteries, potentially reflecting an increase in coronary atherosclerosis in this female study population. Key points: • BMI-discordant twins allow the investigation of the influence of lifestyle factors independent from genetic confounders. • Only thirteen obesity-discordant twins were identified underlining the strong genetic component of BMI. • In female twins, a BMI increase is associated with increased coronary late gadolinium enhancement. • Increased late gadolinium enhancement in the coronary vessel wall potentially reflects increased atherosclerosis.",
keywords = "3D-IR-TFE, Coronary, MRI, Twin, Vessel wall scan",
author = "Makowski, {Marcus R.} and Jansen, {Christian H.P.} and Ullrich Ebersberger and Tobias Schaeffter and Reza Razavi and Massimo Mangino and Spector, {Tim D.} and Botnar, {Rene M.} and Greil, {Gerald F.}",
note = "Funding Information: Acknowledgments The scientific guarantor of this publication is M. Makowski. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study has received funding by the Department of Health through the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London and King{\textquoteright}s College Hospital NHS Foundation Trust. The Division of Imaging Sciences receives also support as the Centre of Excellence in Medical Engineering (funded by the Wellcome Trust and EPSRC; grant number WT 088641/Z/09/Z) as well as the BHF Centre of Excellence (British Heart Foundation award RE/08/03). Further support is received from the Medical Research Council (MRC) Centre for Transplantation, King's College London, UK – MRC grant no. MR/ J006742/1 and a British Heart Foundation program and project grant (RG/12/1/29262, PG/10/044/28343). Dr. Razavi receives investigator-led research grant funding from Philips Healthcare. The study was also partly supported by the Wellcome Trust; European Community{\textquoteright}s Seventh Framework Programme (FP7/2007-2013). The magnetic resonance imaging scanner is partly supported by Philips Healthcare. Otherwise, there are no financial or other relations that could lead to a conflict of interest. No complex statistical methods were necessary for this paper. Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, observational, performed at one institution. Funding Information: The original version of this article was revised: The article was originally published electronically on the publisher_s internet portal (currently SpringerLink) on 14. October 2016 without open access. As the study was partly supported by the Wellcome Trust the article has been modified. The copyright of the article changed to {\textcopyright} The Author(s) [2016] and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License. Funding Information: The scientific guarantor of this publication is M. Makowski. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study has received funding by the Department of Health through the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London and King?s College Hospital NHS Foundation Trust. The Division of Imaging Sciences receives also support as the Centre of Excellence in Medical Engineering (funded by the Wellcome Trust and EPSRC; grant number WT 088641/Z/09/Z) as well as the BHF Centre of Excellence (British Heart Foundation award RE/08/03). Further support is received from the Medical Research Council (MRC) Centre for Transplantation, King's College London, UK ? MRC grant no. MR/J006742/1 and a British Heart Foundation program and project grant (RG/12/1/29262, PG/10/044/28343). Dr. Razavi receives investigator-led research grant funding from Philips Healthcare. The study was also partly supported by the Wellcome Trust; European Community?s Seventh Framework Programme (FP7/2007-2013). The magnetic resonance imaging scanner is partly supported by Philips Healthcare. Otherwise, there are no financial or other relations that could lead to a conflict of interest. No complex statistical methods were necessary for this paper. Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, observational, performed at one institution. The original version of this article was revised:The article was originally published electronically on the publisher?s internet portal (currently SpringerLink) on 14. October 2016 without open access. As the study was partly supported by the Wellcome Trust the article has been modified. The copyright of the article changed to ? The Author(s) [2016] and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License. Rene Botnar and Gerald Greil contributed equally to this work. An erratum to this article is available at https://doi.org/10.1007/s00330-017-4884-y. Publisher Copyright: {\textcopyright} 2016, European Society of Radiology.",
year = "2017",
month = nov,
day = "1",
doi = "10.1007/s00330-016-4616-8",
language = "English (US)",
volume = "27",
pages = "4612--4618",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "11",
}