Inflammatory mediators of liver ischemia-reperfusion injury

Kyle B. Walsh, Alexander H. Toledo, Fernando A. Rivera-Chavez, Fernando Lopez-Neblina, Luis H. Toledo-Pereyra

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


Liver ischemia and reperfusion - which cause liver damage that is significant in a variety of diseases, injuries, and procedures (including but not limited to trauma and transplant) - have been the focus of many investigations in recent years. Although the mechanisms of ischemia-reperfusion injury are numerous and complex,many advances in treatment have been made. The following review considers recent advances in the understanding of hepatic ischemia-reperfusion injury and focuses on inflammatory mediators of significance. To provide a unique analysis and evaluation, we emphasized the most recent pertinent investigations of the last decade. Specific topics addressed include reactive oxygen species, nitric oxide, toll-like receptors, ischemic preconditioning, T cells, heme oxygenase-1, heat shock proteins, erythropoietin, selectins, protein kinases, matrix metalloproteinases, and cytokines.

Original languageEnglish (US)
Pages (from-to)78-93
Number of pages16
JournalExperimental and Clinical Transplantation
Issue number2
StatePublished - Jun 2009


  • Inflammatory mediators
  • Ischemia and reperfusion
  • Liver
  • Transplant
  • Trauma

ASJC Scopus subject areas

  • Transplantation


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