TY - JOUR
T1 - Inflammatory mediators of liver ischemia-reperfusion injury
AU - Walsh, Kyle B.
AU - Toledo, Alexander H.
AU - Rivera-Chavez, Fernando A.
AU - Lopez-Neblina, Fernando
AU - Toledo-Pereyra, Luis H.
PY - 2009/6
Y1 - 2009/6
N2 - Liver ischemia and reperfusion - which cause liver damage that is significant in a variety of diseases, injuries, and procedures (including but not limited to trauma and transplant) - have been the focus of many investigations in recent years. Although the mechanisms of ischemia-reperfusion injury are numerous and complex,many advances in treatment have been made. The following review considers recent advances in the understanding of hepatic ischemia-reperfusion injury and focuses on inflammatory mediators of significance. To provide a unique analysis and evaluation, we emphasized the most recent pertinent investigations of the last decade. Specific topics addressed include reactive oxygen species, nitric oxide, toll-like receptors, ischemic preconditioning, T cells, heme oxygenase-1, heat shock proteins, erythropoietin, selectins, protein kinases, matrix metalloproteinases, and cytokines.
AB - Liver ischemia and reperfusion - which cause liver damage that is significant in a variety of diseases, injuries, and procedures (including but not limited to trauma and transplant) - have been the focus of many investigations in recent years. Although the mechanisms of ischemia-reperfusion injury are numerous and complex,many advances in treatment have been made. The following review considers recent advances in the understanding of hepatic ischemia-reperfusion injury and focuses on inflammatory mediators of significance. To provide a unique analysis and evaluation, we emphasized the most recent pertinent investigations of the last decade. Specific topics addressed include reactive oxygen species, nitric oxide, toll-like receptors, ischemic preconditioning, T cells, heme oxygenase-1, heat shock proteins, erythropoietin, selectins, protein kinases, matrix metalloproteinases, and cytokines.
KW - Inflammatory mediators
KW - Ischemia and reperfusion
KW - Liver
KW - Transplant
KW - Trauma
UR - http://www.scopus.com/inward/record.url?scp=70350496017&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350496017&partnerID=8YFLogxK
M3 - Review article
C2 - 19715511
AN - SCOPUS:70350496017
SN - 1304-0855
VL - 7
SP - 78
EP - 93
JO - Experimental and Clinical Transplantation
JF - Experimental and Clinical Transplantation
IS - 2
ER -