Inflammatory Biomarkers of Birth Asphyxia

Lina F. Chalak

doi:10.1016/j.clp.2016.04.008

Inflammatory Biomarkers of Birth Asphyxia

Lina F. Chalak

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Although therapies in addition to whole-body cooling are being developed to treat the neonate at risk for hypoxic-ischemic encephalopathy, we have no quickly measured serum inflammatory or neuronal biomarkers to acutely and accurately identify brain injury or to follow the efficacy of therapy. This review covers inflammatory serum biomarkers in the setting of birth asphyxia that can help assess the degree or severity of encephalopathy at birth and neurodevelopmental outcomes. These biomarkers still need to be independently validated in large cohorts before they are ready for clinical implementation in practice.

Original language	English (US)
Pages (from-to)	501-510
Number of pages	10
Journal	Clinics in Perinatology
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.clp.2016.04.008
State	Published - Sep 1 2016

Keywords

Asphyxia
Cytokines
GFAP
Placenta
Ubiquitin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1016/j.clp.2016.04.008

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abstract = "Although therapies in addition to whole-body cooling are being developed to treat the neonate at risk for hypoxic-ischemic encephalopathy, we have no quickly measured serum inflammatory or neuronal biomarkers to acutely and accurately identify brain injury or to follow the efficacy of therapy. This review covers inflammatory serum biomarkers in the setting of birth asphyxia that can help assess the degree or severity of encephalopathy at birth and neurodevelopmental outcomes. These biomarkers still need to be independently validated in large cohorts before they are ready for clinical implementation in practice.",

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AB - Although therapies in addition to whole-body cooling are being developed to treat the neonate at risk for hypoxic-ischemic encephalopathy, we have no quickly measured serum inflammatory or neuronal biomarkers to acutely and accurately identify brain injury or to follow the efficacy of therapy. This review covers inflammatory serum biomarkers in the setting of birth asphyxia that can help assess the degree or severity of encephalopathy at birth and neurodevelopmental outcomes. These biomarkers still need to be independently validated in large cohorts before they are ready for clinical implementation in practice.

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KW - Cytokines

KW - GFAP

KW - Placenta

KW - Ubiquitin

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Inflammatory Biomarkers of Birth Asphyxia

Abstract

Keywords

ASJC Scopus subject areas

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