Inflammation and Depression: the Neuroimmune Connection

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


PurposeTo update clinicians on the field of psychoneuroimmunology with respect to depression. Recent findingsA significant subset of patients with depression may have illness to which dysfunction of the immune system, typically viewed as inflammation, makes a significant contribution. Normal sickness behavior may sometimes manifest abnormally as mood episodes. Early evidence suggests that interventions that reduce inflammation may improve symptoms in these patients and that they may also respond differently to standard pharmacotherapy. SummaryTreatment of patients with depression should consider inflammatory status, as part of medical and psychiatric health. Recommendations for healthy diet and exercise are important for all patients but may be more important for patients who have clinical evidence of inflammation. Methods of identifying patients in the inflammatory subgroup and treating them with therapy targeted specifically at the immune system are still experimental but likely to impact care for depression in the future.

Original languageEnglish (US)
Pages (from-to)452-458
Number of pages7
JournalCurrent Treatment Options in Psychiatry
Issue number4
StatePublished - Dec 1 2018
Externally publishedYes


  • Depression
  • Immune System
  • Inflamation
  • Psychoneuroimmunology

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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