Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair

Xingyu Wang; Wanming Zhao; Richard M. Ransohoff; Lan Zhou

doi:10.1016/j.jneuroim.2018.01.004

Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair

Xingyu Wang, Wanming Zhao, Richard M. Ransohoff, Lan Zhou

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Acute skeletal muscle injury repair requires an adequate inflammatory response predominated by macrophage infiltration. We studied the activation of infiltrating macrophages by analyzing the expression of M1/M2 signature genes. Most of the intramuscular macrophages were Ly6C ^hi at day 1 after BaCl ₂ injection, while many were Ly6C ^lo at day 3. Ly6C ^hi macrophages at day 1 expressed a high level of both M1 and M2 genes, and the Ly6C ^hi and Ly6C ^lo macrophages at day 3 expressed a similar level of many M1/M2 genes. Infiltrating macrophages are broadly activated rather than polarized at the early stage to support acute skeletal muscle injury repair.

Original language	English (US)
Pages (from-to)	55-66
Number of pages	12
Journal	Journal of Neuroimmunology
Volume	317
DOIs	https://doi.org/10.1016/j.jneuroim.2018.01.004
State	Published - Apr 15 2018

Keywords

M1/M2
Macrophage activation
Muscle regeneration
Skeletal muscle injury

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/j.jneuroim.2018.01.004

Cite this

@article{9bd1c8dd533b410ba8b7ba430b40439f,

title = "Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair",

abstract = " Acute skeletal muscle injury repair requires an adequate inflammatory response predominated by macrophage infiltration. We studied the activation of infiltrating macrophages by analyzing the expression of M1/M2 signature genes. Most of the intramuscular macrophages were Ly6C hi at day 1 after BaCl 2 injection, while many were Ly6C lo at day 3. Ly6C hi macrophages at day 1 expressed a high level of both M1 and M2 genes, and the Ly6C hi and Ly6C lo macrophages at day 3 expressed a similar level of many M1/M2 genes. Infiltrating macrophages are broadly activated rather than polarized at the early stage to support acute skeletal muscle injury repair.",

keywords = "M1/M2, Macrophage activation, Muscle regeneration, Skeletal muscle injury",

author = "Xingyu Wang and Wanming Zhao and Ransohoff, {Richard M.} and Lan Zhou",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

month = apr,

day = "15",

doi = "10.1016/j.jneuroim.2018.01.004",

language = "English (US)",

volume = "317",

pages = "55--66",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

}

TY - JOUR

T1 - Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair

AU - Wang, Xingyu

AU - Zhao, Wanming

AU - Ransohoff, Richard M.

AU - Zhou, Lan

PY - 2018/4/15

Y1 - 2018/4/15

N2 - Acute skeletal muscle injury repair requires an adequate inflammatory response predominated by macrophage infiltration. We studied the activation of infiltrating macrophages by analyzing the expression of M1/M2 signature genes. Most of the intramuscular macrophages were Ly6C hi at day 1 after BaCl 2 injection, while many were Ly6C lo at day 3. Ly6C hi macrophages at day 1 expressed a high level of both M1 and M2 genes, and the Ly6C hi and Ly6C lo macrophages at day 3 expressed a similar level of many M1/M2 genes. Infiltrating macrophages are broadly activated rather than polarized at the early stage to support acute skeletal muscle injury repair.

AB - Acute skeletal muscle injury repair requires an adequate inflammatory response predominated by macrophage infiltration. We studied the activation of infiltrating macrophages by analyzing the expression of M1/M2 signature genes. Most of the intramuscular macrophages were Ly6C hi at day 1 after BaCl 2 injection, while many were Ly6C lo at day 3. Ly6C hi macrophages at day 1 expressed a high level of both M1 and M2 genes, and the Ly6C hi and Ly6C lo macrophages at day 3 expressed a similar level of many M1/M2 genes. Infiltrating macrophages are broadly activated rather than polarized at the early stage to support acute skeletal muscle injury repair.

KW - M1/M2

KW - Macrophage activation

KW - Muscle regeneration

KW - Skeletal muscle injury

UR - http://www.scopus.com/inward/record.url?scp=85040109628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040109628&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2018.01.004

DO - 10.1016/j.jneuroim.2018.01.004

M3 - Article

C2 - 29325905

AN - SCOPUS:85040109628

SN - 0165-5728

VL - 317

SP - 55

EP - 66

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this