TY - JOUR
T1 - Infiltrating macrophages are broadly activated at the early stage to support acute skeletal muscle injury repair
AU - Wang, Xingyu
AU - Zhao, Wanming
AU - Ransohoff, Richard M.
AU - Zhou, Lan
N1 - Funding Information:
This study is supported by the U.S. National Institutes of Health/NIAMS grant R01AR059702 (LZ) and the institutional funds from the Icahn School of Medicine at Mount Sinai and UT Southwestern Medical Center.
Funding Information:
This study is supported by the U.S. National Institutes of Health /NIAMS grant R01AR059702 (LZ) and the institutional funds from the Icahn School of Medicine at Mount Sinai and UT Southwestern Medical Center .
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/4/15
Y1 - 2018/4/15
N2 - Acute skeletal muscle injury repair requires an adequate inflammatory response predominated by macrophage infiltration. We studied the activation of infiltrating macrophages by analyzing the expression of M1/M2 signature genes. Most of the intramuscular macrophages were Ly6C hi at day 1 after BaCl 2 injection, while many were Ly6C lo at day 3. Ly6C hi macrophages at day 1 expressed a high level of both M1 and M2 genes, and the Ly6C hi and Ly6C lo macrophages at day 3 expressed a similar level of many M1/M2 genes. Infiltrating macrophages are broadly activated rather than polarized at the early stage to support acute skeletal muscle injury repair.
AB - Acute skeletal muscle injury repair requires an adequate inflammatory response predominated by macrophage infiltration. We studied the activation of infiltrating macrophages by analyzing the expression of M1/M2 signature genes. Most of the intramuscular macrophages were Ly6C hi at day 1 after BaCl 2 injection, while many were Ly6C lo at day 3. Ly6C hi macrophages at day 1 expressed a high level of both M1 and M2 genes, and the Ly6C hi and Ly6C lo macrophages at day 3 expressed a similar level of many M1/M2 genes. Infiltrating macrophages are broadly activated rather than polarized at the early stage to support acute skeletal muscle injury repair.
KW - M1/M2
KW - Macrophage activation
KW - Muscle regeneration
KW - Skeletal muscle injury
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U2 - 10.1016/j.jneuroim.2018.01.004
DO - 10.1016/j.jneuroim.2018.01.004
M3 - Article
C2 - 29325905
AN - SCOPUS:85040109628
SN - 0165-5728
VL - 317
SP - 55
EP - 66
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
ER -