Infectious and granulomatous neuropathies

Sharon P Nations, Jaya R Trivedi, Gil I. Wolfe

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Infectious and granulomatous neuropathies, including those associated with leprosy, Lyme disease, and sarcoidosis, share a number of clinical features. Asymmetric sensory and motor nerve involvement are typical, and cranial neuropathies are common, and help to distinguish infectious and granulomatous neuropathies from more common etiologies of peripheral nerve injury. Herpes zoster represents a re-activation of latent varicella zoster infection, and also results in asymmetric sensory loss, and less commonly weakness, in a radicular pattern. The diagnosis of infectious and granulomatous neuropathies rests on recognition of typical systemic involvement, serologic testing, and appropriate biopsy material. The diagnosis of herpetic neuropathies is made from the clinical features. Polymerase chain reaction techniques have an increasingly important role in diagnosis. Specific treatments are available for most infectious and granulomatous neuropathies and are generally effective in either reversing nerve damage or preventing further impairment. The prognosis is favorable when the cause is identified early in the disease course, but if treatment is delayed, permanent axonal damage is common in later stages. Herpetic neuropathies can be treated and post-herpetic pain successfully managed.

Original languageEnglish (US)
Title of host publicationHandbook of Peripheral Neuropathy
PublisherCRC Press
Number of pages21
ISBN (Electronic)9780849354861
ISBN (Print)9780824754327
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Medicine(all)
  • Health Professions(all)


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