Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker Diabetic Fatty rats

Michio Shimabukuro; Yan Ting Zhou; Young H Lee; Roger H Unger

doi:10.1006/bbrc.1997.7140

Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker Diabetic Fatty rats

Michio Shimabukuro, Yan Ting Zhou, Young H Lee, Roger H Unger

Research output: Contribution to journal › Article › peer-review

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Abstract

Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions. Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese Zucker Diabetic Fatty (ZDF) rats with mutated leptin receptors. We report here that troglitazone also increases the UCP-2/β-actin mRNA ratio by 115% in wild type ZDF rats and by 400% in obese ZDF rats.

Original language	English (US)
Pages (from-to)	359-361
Number of pages	3
Journal	Biochemical and Biophysical Research Communications
Volume	237
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1997.7140
State	Published - Aug 18 1997

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker Diabetic Fatty rats",

abstract = "Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions. Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese Zucker Diabetic Fatty (ZDF) rats with mutated leptin receptors. We report here that troglitazone also increases the UCP-2/β-actin mRNA ratio by 115% in wild type ZDF rats and by 400% in obese ZDF rats.",

author = "Michio Shimabukuro and Zhou, {Yan Ting} and Lee, {Young H} and Unger, {Roger H}",

note = "Funding Information: This work was supported by NIH Grant DK02700-37, NIH/JDF Diabetes Interdisciplinary Research Program, and Veterans Administration Institutional Research Support Grant SMI 821-109. We thank Falguani Trieu and Xue Yan for technical assistance. Animal care was in accord with institutional guidelines.",

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AU - Zhou, Yan Ting

AU - Lee, Young H

AU - Unger, Roger H

N1 - Funding Information: This work was supported by NIH Grant DK02700-37, NIH/JDF Diabetes Interdisciplinary Research Program, and Veterans Administration Institutional Research Support Grant SMI 821-109. We thank Falguani Trieu and Xue Yan for technical assistance. Animal care was in accord with institutional guidelines.

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N2 - Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions. Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese Zucker Diabetic Fatty (ZDF) rats with mutated leptin receptors. We report here that troglitazone also increases the UCP-2/β-actin mRNA ratio by 115% in wild type ZDF rats and by 400% in obese ZDF rats.

AB - Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions. Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese Zucker Diabetic Fatty (ZDF) rats with mutated leptin receptors. We report here that troglitazone also increases the UCP-2/β-actin mRNA ratio by 115% in wild type ZDF rats and by 400% in obese ZDF rats.

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Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker Diabetic Fatty rats

Abstract

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