Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp.

Peng Fu; Matthew Jamison; Scott La; John B. MacMillan

doi:10.1021/ol502731p

Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp.

Peng Fu, Matthew Jamison, Scott La, John B. MacMillan

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42 Scopus citations

Abstract

Inducamides A-C (1-3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were isolated from a chemically induced mutant strain of Streptomyces sp. with the inducamides only being produced in the mutant strain. Their structures, including stereochemistry, were determined by spectroscopic analysis, Marfey's method, and CD spectroscopy.

Original language	English (US)
Pages (from-to)	5656-5659
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	21
DOIs	https://doi.org/10.1021/ol502731p
State	Published - Nov 7 2014

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol502731p

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abstract = "Inducamides A-C (1-3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were isolated from a chemically induced mutant strain of Streptomyces sp. with the inducamides only being produced in the mutant strain. Their structures, including stereochemistry, were determined by spectroscopic analysis, Marfey's method, and CD spectroscopy.",

author = "Peng Fu and Matthew Jamison and Scott La and MacMillan, {John B.}",

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AU - Jamison, Matthew

AU - La, Scott

AU - MacMillan, John B.

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AB - Inducamides A-C (1-3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were isolated from a chemically induced mutant strain of Streptomyces sp. with the inducamides only being produced in the mutant strain. Their structures, including stereochemistry, were determined by spectroscopic analysis, Marfey's method, and CD spectroscopy.

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Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp.

Abstract

ASJC Scopus subject areas

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