Indirubins inhibit glycogen synthase kinase-3β and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Sophie Leclerc, Matthieu Garnier, Ralph Hoessel, Doris Marko, James A. Bibb, Gretchen L. Snyder, Paul Greengard, Jacek Biernat, Yong Zhong Wu, Eva Maria Mandelkow, Gerhard Eisenbrand, Laurent Meijert
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