Independent stem cell lineages regulate adipose organogenesis and adipose homeostasis

Yuwei Jiang, Daniel C. Berry, Wei Tang, Jonathan M. Graff

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


Adipose tissues have striking plasticity, highlighted by childhood and adult obesity. Using adipose lineage analyses, smooth muscle actin (SMA)-mural cell-fate mapping, and conditional PPARγ deletion to block adipocyte differentiation, we find two phases of adipocyte generation that emanate from two independent adipose progenitor compartments: developmental and adult. These two compartments are sequentially required for organ formation and maintenance. Although both developmental and adult progenitors are specified during the developmental period and express PPARγ, they have distinct microanatomical, functional, morphogenetic, and molecular profiles. Furthermore, the two compartments derive from different lineages; whereas adult adipose progenitors fate-map from an SMA+ mural lineage, developmental progenitors do not. Remarkably, the adult progenitor compartment appears to be specified earlier than the developmental cells and then enters the already developmentally formed adipose depots. Thus, two distinct cell compartments control adipose organ development and organ homeostasis, which may provide a discrete therapeutic target for childhood and adult obesity.

Original languageEnglish (US)
Pages (from-to)1007-1022
Number of pages16
JournalCell Reports
Issue number3
StatePublished - 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Independent stem cell lineages regulate adipose organogenesis and adipose homeostasis'. Together they form a unique fingerprint.

Cite this