Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: Role of nonstructural component 5A and CCAAT/enhancer-binding protein β

Ishtiaq Qadri; Mahua Choudhury; Shaikh Mizanoor Rahman; Trina A. Knotts; Rachel C. Janssen; Jerome Schaack; Mieko Iwahashi; Livia Puljak; Francis R. Simon; Gordan Kilic; Gregory Fitz; Jacob E. Friedman

doi:10.1074/jbc.M112.384743

Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: Role of nonstructural component 5A and CCAAT/enhancer-binding protein β

Ishtiaq Qadri, Mahua Choudhury, Shaikh Mizanoor Rahman, Trina A. Knotts, Rachel C. Janssen, Jerome Schaack, Mieko Iwahashi, Livia Puljak, Francis R. Simon, Gordan Kilic, Gregory Fitz, Jacob E. Friedman

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Background: Chronic hepatitis C virus (HCV) infection increases the risk of type 2 diabetes and hepatic steatosis. Results: Phosphoenolpyruvate carboxykinase (PEPCK) and associated transcription factors are up-regulated in HCV-infected Huh.8 cells. Conclusion: Increased CCAAT/enhancer-binding protein β (C/EBPβ) and nonstructural component 5A (NS5A) are essential components for increased gluconeogenesis. Significance: NS5A and C/EBPβ may possibly be considered as a new pharmacological target during HCV infection.

Original language	English (US)
Pages (from-to)	37340-37351
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.384743
State	Published - Oct 26 2012

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Qadri, I., Choudhury, M., Rahman, S. M., Knotts, T. A., Janssen, R. C., Schaack, J., Iwahashi, M., Puljak, L., Simon, F. R., Kilic, G., Fitz, G., & Friedman, J. E. (2012). Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: Role of nonstructural component 5A and CCAAT/enhancer-binding protein β. Journal of Biological Chemistry, 287(44), 37340-37351. https://doi.org/10.1074/jbc.M112.384743

Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: Role of nonstructural component 5A and CCAAT/enhancer-binding protein β. / Qadri, Ishtiaq; Choudhury, Mahua; Rahman, Shaikh Mizanoor et al.
In: Journal of Biological Chemistry, Vol. 287, No. 44, 26.10.2012, p. 37340-37351.

Research output: Contribution to journal › Article › peer-review

Qadri, I, Choudhury, M, Rahman, SM, Knotts, TA, Janssen, RC, Schaack, J, Iwahashi, M, Puljak, L, Simon, FR, Kilic, G, Fitz, G & Friedman, JE 2012, 'Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: Role of nonstructural component 5A and CCAAT/enhancer-binding protein β', Journal of Biological Chemistry, vol. 287, no. 44, pp. 37340-37351. https://doi.org/10.1074/jbc.M112.384743

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title = "Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: Role of nonstructural component 5A and CCAAT/enhancer-binding protein β",

abstract = "Background: Chronic hepatitis C virus (HCV) infection increases the risk of type 2 diabetes and hepatic steatosis. Results: Phosphoenolpyruvate carboxykinase (PEPCK) and associated transcription factors are up-regulated in HCV-infected Huh.8 cells. Conclusion: Increased CCAAT/enhancer-binding protein β (C/EBPβ) and nonstructural component 5A (NS5A) are essential components for increased gluconeogenesis. Significance: NS5A and C/EBPβ may possibly be considered as a new pharmacological target during HCV infection.",

author = "Ishtiaq Qadri and Mahua Choudhury and Rahman, {Shaikh Mizanoor} and Knotts, {Trina A.} and Janssen, {Rachel C.} and Jerome Schaack and Mieko Iwahashi and Livia Puljak and Simon, {Francis R.} and Gordan Kilic and Gregory Fitz and Friedman, {Jacob E.}",

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doi = "10.1074/jbc.M112.384743",

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AU - Choudhury, Mahua

AU - Rahman, Shaikh Mizanoor

AU - Knotts, Trina A.

AU - Janssen, Rachel C.

AU - Schaack, Jerome

AU - Iwahashi, Mieko

AU - Puljak, Livia

AU - Simon, Francis R.

AU - Kilic, Gordan

AU - Fitz, Gregory

AU - Friedman, Jacob E.

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N2 - Background: Chronic hepatitis C virus (HCV) infection increases the risk of type 2 diabetes and hepatic steatosis. Results: Phosphoenolpyruvate carboxykinase (PEPCK) and associated transcription factors are up-regulated in HCV-infected Huh.8 cells. Conclusion: Increased CCAAT/enhancer-binding protein β (C/EBPβ) and nonstructural component 5A (NS5A) are essential components for increased gluconeogenesis. Significance: NS5A and C/EBPβ may possibly be considered as a new pharmacological target during HCV infection.

AB - Background: Chronic hepatitis C virus (HCV) infection increases the risk of type 2 diabetes and hepatic steatosis. Results: Phosphoenolpyruvate carboxykinase (PEPCK) and associated transcription factors are up-regulated in HCV-infected Huh.8 cells. Conclusion: Increased CCAAT/enhancer-binding protein β (C/EBPβ) and nonstructural component 5A (NS5A) are essential components for increased gluconeogenesis. Significance: NS5A and C/EBPβ may possibly be considered as a new pharmacological target during HCV infection.

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Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: Role of nonstructural component 5A and CCAAT/enhancer-binding protein β

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