Increased hippocampal volume in schizophrenics' parents with ancestral history of schizophrenia

Josette G. Harris, David A. Young, Donald C. Rojas, Ana Cajade-Law, Ann Scherzinger, Safia Nawroz, Lawrence E. Adler, C. Munro Cullum, Jack Simon, Robert Freedman

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective: Decreased hippocampal volume is one of the hypothesized pathological features of schizophrenia, but it is not known if this abnormality is familially transmitted. The aim of this study was to measure the hippocampal volume of the parents of schizophrenic probands, in relationship to the apparent transmission of genetic risk. Method: Eighteen subjects from families consisting of a schizophrenic proband and two clinically unaffected parents were studied. Probands were compared to six control subjects, matched for age, sex, and educational level. The six families were selected so that only one parent had an ancestral family history of schizophrenia. The volumes of both hippocampi were measured by magnetic resonance imaging and adjusted for age and whole brain volume. Results: The total hippocampal volumes of the parents with ancestral family history of schizophrenia were significantly larger than those of their schizophrenic offspring. Conclusions: This study suggests that decreased hippocampal volume in schizophrenia is not a familially transmitted abnormality. Rather, it appears that clinically unaffected parents who transmit apparent genetic risk for schizophrenia may have increased hippocampal volume, which may be a protective factor against the illness.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalSchizophrenia Research
Issue number1-2
StatePublished - May 1 2002

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


Dive into the research topics of 'Increased hippocampal volume in schizophrenics' parents with ancestral history of schizophrenia'. Together they form a unique fingerprint.

Cite this