TY - JOUR
T1 - Increased fasting plasma insulin concentrations are associated with the severity of angiographic coronary artery disease
AU - Sukhija, Rishi
AU - Aronow, Wilbert S.
AU - Nayak, Devraj
AU - Ahn, Chul
AU - Weiss, Melvin B.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/5
Y1 - 2005/5
N2 - Fasting plasma insulin concentrations were obtained in 82 patients (51 men and 31 women), mean age 60 ± 11 years, with a body mass index >25 kg/m2 who had coronary angiography because of suspected symptomatic coronary artery disease (CAD). Obstructive CAD was diagnosed if there was >50% obstruction of ≥1 vessel. Of 82 patients, 37 (45%) had left main or 3-vessel CAD, 22 (27%) had 2-vessel CAD, 9(11%) had 1-vessel CAD, and 14(17%) had no obstructive CAD. Among the 4 groups, there was no significant difference in gender, age, dyslipidemia, and smoking. Hypertension (p = 0.0003), diabetes mellitus (p = 0.035), and increased fasting plasma insulin concentration (p < 0.0001) were significantly associated with the severity of CAD. Stepwise ordinal logistic regression analysis identified increased fasting plasma insulin concentrations in these obese subjects as a significant independent risk factor for the severity of angiographic CAD (p < 0.0001).
AB - Fasting plasma insulin concentrations were obtained in 82 patients (51 men and 31 women), mean age 60 ± 11 years, with a body mass index >25 kg/m2 who had coronary angiography because of suspected symptomatic coronary artery disease (CAD). Obstructive CAD was diagnosed if there was >50% obstruction of ≥1 vessel. Of 82 patients, 37 (45%) had left main or 3-vessel CAD, 22 (27%) had 2-vessel CAD, 9(11%) had 1-vessel CAD, and 14(17%) had no obstructive CAD. Among the 4 groups, there was no significant difference in gender, age, dyslipidemia, and smoking. Hypertension (p = 0.0003), diabetes mellitus (p = 0.035), and increased fasting plasma insulin concentration (p < 0.0001) were significantly associated with the severity of CAD. Stepwise ordinal logistic regression analysis identified increased fasting plasma insulin concentrations in these obese subjects as a significant independent risk factor for the severity of angiographic CAD (p < 0.0001).
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U2 - 10.1177/000331970505600302
DO - 10.1177/000331970505600302
M3 - Article
C2 - 15889190
AN - SCOPUS:18544384374
SN - 0003-3197
VL - 56
SP - 249
EP - 251
JO - Angiology
JF - Angiology
IS - 3
ER -