Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers

Florencia Pereyra; Janet Lo; Virginia A. Triant; Jeffrey Wei; Maria J. Buzon; Kathleen V. Fitch; Janice Hwang; Jennifer H. Campbell; Tricia H. Burdo; Kenneth C. Williams; Suhny Abbara; Steven K. Grinspoon

doi:10.1097/QAD.0b013e32835a9950

Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers

Florencia Pereyra, Janet Lo, Virginia A. Triant, Jeffrey Wei, Maria J. Buzon, Kathleen V. Fitch, Janice Hwang, Jennifer H. Campbell, Tricia H. Burdo, Kenneth C. Williams, Suhny Abbara, Steven K. Grinspoon

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168 Scopus citations

Abstract

HIV-1 elite controllers spontaneously maintain suppressed levels of viremia, but exhibit significant immune activation. We investigated coronary atherosclerosis by coronary computed tomography angiography (CTA) in elite controllers, nonelite controller, chronically HIV-1 infected, antiretroviral therapy (ART)-treated patients with undetectable viral load ('chronic HIV'), and HIV-negative controls. Prevalence of atherosclerosis (78 vs. 42%, P < 0.05) and markers of immune activation were increased in elite controllers compared with HIV-negative controls. sCD163, a monocyte activation marker, was increased in elite controllers compared with chronic HIV-1 (P < 0.05) and compared with HIV-negative controls (P < 0.05). These data suggest a significant degree of coronary atherosclerosis and monocyte activation among elite controllers.

Original language	English (US)
Pages (from-to)	2409-2412
Number of pages	4
Journal	AIDS
Volume	26
Issue number	18
DOIs	https://doi.org/10.1097/QAD.0b013e32835a9950
State	Published - Nov 28 2012

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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title = "Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers",

abstract = "HIV-1 elite controllers spontaneously maintain suppressed levels of viremia, but exhibit significant immune activation. We investigated coronary atherosclerosis by coronary computed tomography angiography (CTA) in elite controllers, nonelite controller, chronically HIV-1 infected, antiretroviral therapy (ART)-treated patients with undetectable viral load ('chronic HIV'), and HIV-negative controls. Prevalence of atherosclerosis (78 vs. 42%, P < 0.05) and markers of immune activation were increased in elite controllers compared with HIV-negative controls. sCD163, a monocyte activation marker, was increased in elite controllers compared with chronic HIV-1 (P < 0.05) and compared with HIV-negative controls (P < 0.05). These data suggest a significant degree of coronary atherosclerosis and monocyte activation among elite controllers.",

author = "Florencia Pereyra and Janet Lo and Triant, {Virginia A.} and Jeffrey Wei and Buzon, {Maria J.} and Fitch, {Kathleen V.} and Janice Hwang and Campbell, {Jennifer H.} and Burdo, {Tricia H.} and Williams, {Kenneth C.} and Suhny Abbara and Grinspoon, {Steven K.}",

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T1 - Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers

AU - Pereyra, Florencia

AU - Lo, Janet

AU - Triant, Virginia A.

AU - Wei, Jeffrey

AU - Buzon, Maria J.

AU - Fitch, Kathleen V.

AU - Hwang, Janice

AU - Campbell, Jennifer H.

AU - Burdo, Tricia H.

AU - Williams, Kenneth C.

AU - Abbara, Suhny

AU - Grinspoon, Steven K.

PY - 2012/11/28

Y1 - 2012/11/28

N2 - HIV-1 elite controllers spontaneously maintain suppressed levels of viremia, but exhibit significant immune activation. We investigated coronary atherosclerosis by coronary computed tomography angiography (CTA) in elite controllers, nonelite controller, chronically HIV-1 infected, antiretroviral therapy (ART)-treated patients with undetectable viral load ('chronic HIV'), and HIV-negative controls. Prevalence of atherosclerosis (78 vs. 42%, P < 0.05) and markers of immune activation were increased in elite controllers compared with HIV-negative controls. sCD163, a monocyte activation marker, was increased in elite controllers compared with chronic HIV-1 (P < 0.05) and compared with HIV-negative controls (P < 0.05). These data suggest a significant degree of coronary atherosclerosis and monocyte activation among elite controllers.

AB - HIV-1 elite controllers spontaneously maintain suppressed levels of viremia, but exhibit significant immune activation. We investigated coronary atherosclerosis by coronary computed tomography angiography (CTA) in elite controllers, nonelite controller, chronically HIV-1 infected, antiretroviral therapy (ART)-treated patients with undetectable viral load ('chronic HIV'), and HIV-negative controls. Prevalence of atherosclerosis (78 vs. 42%, P < 0.05) and markers of immune activation were increased in elite controllers compared with HIV-negative controls. sCD163, a monocyte activation marker, was increased in elite controllers compared with chronic HIV-1 (P < 0.05) and compared with HIV-negative controls (P < 0.05). These data suggest a significant degree of coronary atherosclerosis and monocyte activation among elite controllers.

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Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers

Abstract

ASJC Scopus subject areas

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