@article{e8a17cd715474129a205ab9c9d6c4bf9,
title = "Increased Climbing Fiber Lateral Crossings on Purkinje Cell Dendrites in the Cerebellar Hemisphere in Essential Tremor",
abstract = "Background: Climbing fibers (CFs) innervate Purkinje cells (PCs) with 1:1 relationship to ensure proper cerebellar function. Although CFs abnormally extend into the parallel fiber domain of PC dendrites in essential tremor (ET), the architecture of CFs in relation to PCs has yet to be investigated in detail. Objective: The aim of this work was to study the architecture of CFs in relation to PCs in ET. Methods: The number of PC somas and PC dendrites that a single CF crossed was quantified in the postmortem cerebellum of 15 ET cases and 15 control cases. Results: In ET, CFs crossed a greater number of PC somas and PC dendrites than in control cases, raising the possibility that there is abnormal CF wiring onto the PCs. Interestingly, the increase in CF–PC crossings positively correlated with tremor severity. Conclusions: Patients with ET have increased CF crossings on PC dendrites. This abnormal architectural arrangement may contribute to synchronous brain activity and tremor.",
keywords = "Purkinje cell, cerebellum, climbing fiber, essential tremor, pathology",
author = "Wu, {Yueh Chi} and Louis, {Elan D.} and John Gionco and Pan, {Ming Kai} and Faust, {Phyllis L.} and Kuo, {Sheng Han}",
note = "Funding Information: E.D.L. has received research support from the National Institutes of Health, National Institute of Neurological Disorders and Stroke (NINDS) #R01 NS094607 (principal investigator), NINDS #R01 NS085136 (principal investigator), NINDS #R01 NS073872 (principal investigator), NINDS #R01 NS085136 (principal investigator), and NINDS #R01 NS088257 (principal investigator). He has also received support from the Claire O'Neil Essential Tremor Research Fund (Yale University). P.L.F. has received funding from the National Institutes of Health, NINDS #R01 NS085136 (principal investigator) and NINDS #R01 NS088257 (principal investigator). M.-K.P. has received funding from the Ministry of Science and Technology in Taiwan [grants MOST 104-2314-B-002-076-MY3 (principal investigator), MOST 107-2321-B-002-020 (principal investigator), MOST 108-2321-B-002-011 (principal investigator), and MOST 108-2321-B-002-059-MY2 (principal investigator)], National Taiwan University Hospital (grants 105-N3227 and 108-039), and Yin-Lin branch of the hospital (grant NTUHYL104.N007). S.-H.K. has received funding from the National Institutes of Health (NINDS #R01 NS104423 (principal investigator), NINDS #R01 NS118179 (principal investigator), NINDS #R03 NS114871 (principal investigator), the Louis V. Gerstner Jr. Scholar Award, National Ataxia Foundation, Parkinson's Foundation, International Essential Tremor Foundation, and Brain Research Foundation. Publisher Copyright: {\textcopyright} 2021 International Parkinson and Movement Disorder Society",
year = "2021",
month = jun,
doi = "10.1002/mds.28502",
language = "English (US)",
volume = "36",
pages = "1440--1445",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "6",
}