TY - JOUR
T1 - Increased adipose tissue insulin resistance in metabolic syndrome
T2 - Relationship to circulating adipokines
AU - Adams-Huet, Beverley
AU - Devaraj, Sridevi
AU - Siegel, David
AU - Jialal, Ishwarlal
N1 - Publisher Copyright:
© Mary Ann Liebert, Inc. 2014.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Background: Although hepatic insulin resistance has been documented in patients with metabolic syndrome using homeostasis model assessment of insulin resistance (HOMA-IR) as a measure, there is scanty data on adipose insulin resistance (Adipo-IR) and its relationship with the dysregulation of adipokines in metabolic syndrome. Thus, we examined whether Adipo-IR is increased in metabolic syndrome as well as its correlation with circulating adipokines. Methods: In 42 individuals including controls and participants with metabolic syndrome, we measured fasting plasma insulin and free fatty acids (FFA). Adipo-IR was calculated as the product of FFA×insulin. We examined the association between Adipo-IR, metabolic syndrome variables, and circulating adipokines, including leptin, adiponectin, chemerin, omentin-1, and retinol-binding protein-4. Results: Adipo-IR was higher in metabolic syndrome (n=19; median 68.7mmol/L·pmol/L; 25th-75th percentile, 50.0-104.7) compared to controls (n=23; 22.9mmol/L·pmol/L; 6.8-36.1; P<0.0001), and this difference was similar following adjustments for waist circumference or body mass index (BMI). Adipo-IR correlated significantly with certain adipokines: Leptin, r=0.45, P=0.004; adiponectin, r=-0.33, P<0.05; chemerin r=0.55, P=0.0008; omentin-1, r=-0.46, P=0.04, and with all features of metabolic syndrome. Conclusions: Adipo-IR is increased in metabolic syndrome following adjustment for adiposity and may be an important biomarker of adipose tissue dysregulation, including adipokine secretion and a potential relevant therapeutic target.
AB - Background: Although hepatic insulin resistance has been documented in patients with metabolic syndrome using homeostasis model assessment of insulin resistance (HOMA-IR) as a measure, there is scanty data on adipose insulin resistance (Adipo-IR) and its relationship with the dysregulation of adipokines in metabolic syndrome. Thus, we examined whether Adipo-IR is increased in metabolic syndrome as well as its correlation with circulating adipokines. Methods: In 42 individuals including controls and participants with metabolic syndrome, we measured fasting plasma insulin and free fatty acids (FFA). Adipo-IR was calculated as the product of FFA×insulin. We examined the association between Adipo-IR, metabolic syndrome variables, and circulating adipokines, including leptin, adiponectin, chemerin, omentin-1, and retinol-binding protein-4. Results: Adipo-IR was higher in metabolic syndrome (n=19; median 68.7mmol/L·pmol/L; 25th-75th percentile, 50.0-104.7) compared to controls (n=23; 22.9mmol/L·pmol/L; 6.8-36.1; P<0.0001), and this difference was similar following adjustments for waist circumference or body mass index (BMI). Adipo-IR correlated significantly with certain adipokines: Leptin, r=0.45, P=0.004; adiponectin, r=-0.33, P<0.05; chemerin r=0.55, P=0.0008; omentin-1, r=-0.46, P=0.04, and with all features of metabolic syndrome. Conclusions: Adipo-IR is increased in metabolic syndrome following adjustment for adiposity and may be an important biomarker of adipose tissue dysregulation, including adipokine secretion and a potential relevant therapeutic target.
UR - http://www.scopus.com/inward/record.url?scp=84911366985&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84911366985&partnerID=8YFLogxK
U2 - 10.1089/met.2014.0092
DO - 10.1089/met.2014.0092
M3 - Article
C2 - 25162912
AN - SCOPUS:84911366985
SN - 1540-4196
VL - 12
SP - 503
EP - 507
JO - Metabolic Syndrome and Related Disorders
JF - Metabolic Syndrome and Related Disorders
IS - 10
ER -