TY - JOUR
T1 - Incidence of mycobacterium avium-intracellulare complex bacteremia in human immunodeficiency virus-positive patients
AU - Nightingale, Stephen D.
AU - Byrd, Linda T.
AU - Southern, Paul M.
AU - Jockusch, Jonathan D.
AU - Cal, Stanley X.
AU - Wynne, Beverley A.
PY - 1992/6
Y1 - 1992/6
N2 - The product-limit incidence of Mycobacterium avium-intracellulare complex (MAC) bacteremia in 1006 human immunodeficiency virus (HIV)-positive patients followed at one institution over a 3-year period from the day of AIDS diagnosis with monthly lysis-centrifugation blood cultures was 21% ± 2% SE at 1 year and 43% ± 3% at 2 years. The product-limit incidence of MAC bacteremia at 1 year after the patients’ first CD4 cell count was related to both the CD4 cell count and to whether they had an AIDS diagnosis (both P <.0001) but not to age, sex, or race. This incidence was 39% ± 6% for CD4 cell counts of <10/mm3,30% ± 5% for 10-19/mm3, 20% ± 4% for 20-39/mm3,15% ± 4% for 40-59/mm3, 8% ± 3% for 60-99/mm3, and 3% ± 1% for 100-199/mm3. MAC may eventually infect most if not all HIV-positive patients who do not die from another HIV-related event.
AB - The product-limit incidence of Mycobacterium avium-intracellulare complex (MAC) bacteremia in 1006 human immunodeficiency virus (HIV)-positive patients followed at one institution over a 3-year period from the day of AIDS diagnosis with monthly lysis-centrifugation blood cultures was 21% ± 2% SE at 1 year and 43% ± 3% at 2 years. The product-limit incidence of MAC bacteremia at 1 year after the patients’ first CD4 cell count was related to both the CD4 cell count and to whether they had an AIDS diagnosis (both P <.0001) but not to age, sex, or race. This incidence was 39% ± 6% for CD4 cell counts of <10/mm3,30% ± 5% for 10-19/mm3, 20% ± 4% for 20-39/mm3,15% ± 4% for 40-59/mm3, 8% ± 3% for 60-99/mm3, and 3% ± 1% for 100-199/mm3. MAC may eventually infect most if not all HIV-positive patients who do not die from another HIV-related event.
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U2 - 10.1093/infdis/165.6.1082
DO - 10.1093/infdis/165.6.1082
M3 - Article
C2 - 1349906
AN - SCOPUS:0026563214
SN - 0022-1899
VL - 165
SP - 1082
EP - 1085
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -