TY - JOUR
T1 - In vivo stereological assessment of human cerebellar volume
T2 - Effects of gender and age
AU - Escalona, P. R.
AU - McDonald, W. M.
AU - Doraiswamy, P. M.
AU - Boyko, O. B.
AU - Husain, M. M.
AU - Figiel, G. S.
AU - Laskowitz, D.
AU - Ellinwood, E. H.
AU - Krishnan, K. R R
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1991
Y1 - 1991
N2 - Intermediate T2-weighted MR images and a systematic sampling stereological method were used in 37 normal volunteers, 24 to 79 years old, to assess the effects of age and sex on cerebellar volume. Female subjects (n = 21) had significantly smaller cerebellar volumes compared with males (n = 16) of similar age (t = -3.9, p < .0008, two-tail t test). Using straight-line, univariate regression, we determined that age was not a significant predictor of cerebellar volume (R2 = 0.07, t = -1.66, p = 0.11), whereas gender did appear to account for a significant amount of variability in cerebellar volume (R2 = 0.33, t = -4.13, p = .0002). The mean absolute cerebellar volume in this study was 112 ml (SD ± 16) for all subjects, 104 ml (SD ± 10) for females, and 122 ml (SD ± 16) for males. This study demonstrates the feasibility of using MR images along with a systematic stereological method to assess in vivo human cerebellar volume, thereby providing a research tool to correlate cerebellar morphology with cognitive and neuromotor function.
AB - Intermediate T2-weighted MR images and a systematic sampling stereological method were used in 37 normal volunteers, 24 to 79 years old, to assess the effects of age and sex on cerebellar volume. Female subjects (n = 21) had significantly smaller cerebellar volumes compared with males (n = 16) of similar age (t = -3.9, p < .0008, two-tail t test). Using straight-line, univariate regression, we determined that age was not a significant predictor of cerebellar volume (R2 = 0.07, t = -1.66, p = 0.11), whereas gender did appear to account for a significant amount of variability in cerebellar volume (R2 = 0.33, t = -4.13, p = .0002). The mean absolute cerebellar volume in this study was 112 ml (SD ± 16) for all subjects, 104 ml (SD ± 10) for females, and 122 ml (SD ± 16) for males. This study demonstrates the feasibility of using MR images along with a systematic stereological method to assess in vivo human cerebellar volume, thereby providing a research tool to correlate cerebellar morphology with cognitive and neuromotor function.
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M3 - Article
C2 - 1950923
AN - SCOPUS:0026094434
SN - 0195-6108
VL - 12
SP - 927
EP - 929
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
IS - 5
ER -