In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia.

C. R. Malloy; P. M. Matthews; M. B. Smith; G. K. Radda

In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia.

C. R. Malloy, P. M. Matthews, M. B. Smith, G. K. Radda

Research output: Contribution to journal › Article › peer-review

Abstract

We applied 31P nuclear magnetic resonance to the study of acute ischemia in vivo. In open-chest rabbits, the left anterior descending coronary artery was occluded after control spectra were obtained. Phosphocreatine concentration decreased in the first minute and ATP concentration declined subsequently, and pH decreased to 5.8 within 20 min. Intracellular acidosis was greater than that previously reported for the isolated perfused rabbit heart.

Original language	English (US)
Pages (from-to)	461-464
Number of pages	4
Journal	Advances in myocardiology
Volume	6
State	Published - 1985

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia.",

abstract = "We applied 31P nuclear magnetic resonance to the study of acute ischemia in vivo. In open-chest rabbits, the left anterior descending coronary artery was occluded after control spectra were obtained. Phosphocreatine concentration decreased in the first minute and ATP concentration declined subsequently, and pH decreased to 5.8 within 20 min. Intracellular acidosis was greater than that previously reported for the isolated perfused rabbit heart.",

author = "Malloy, {C. R.} and Matthews, {P. M.} and Smith, {M. B.} and Radda, {G. K.}",

year = "1985",

language = "English (US)",

volume = "6",

pages = "461--464",

journal = "Advances in myocardiology",

issn = "0270-4056",

publisher = "Plenum Publishers",

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T1 - In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia.

AU - Malloy, C. R.

AU - Matthews, P. M.

AU - Smith, M. B.

AU - Radda, G. K.

PY - 1985

Y1 - 1985

N2 - We applied 31P nuclear magnetic resonance to the study of acute ischemia in vivo. In open-chest rabbits, the left anterior descending coronary artery was occluded after control spectra were obtained. Phosphocreatine concentration decreased in the first minute and ATP concentration declined subsequently, and pH decreased to 5.8 within 20 min. Intracellular acidosis was greater than that previously reported for the isolated perfused rabbit heart.

AB - We applied 31P nuclear magnetic resonance to the study of acute ischemia in vivo. In open-chest rabbits, the left anterior descending coronary artery was occluded after control spectra were obtained. Phosphocreatine concentration decreased in the first minute and ATP concentration declined subsequently, and pH decreased to 5.8 within 20 min. Intracellular acidosis was greater than that previously reported for the isolated perfused rabbit heart.

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M3 - Article

C2 - 3992043

AN - SCOPUS:0021982197

SN - 0270-4056

VL - 6

SP - 461

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JO - Advances in myocardiology

JF - Advances in myocardiology

ER -

In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia.

Abstract

ASJC Scopus subject areas

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