In vivo microscopy

Anne Marie Amacher, Christopher A. Garcia, Andrew Quinn

Research output: Chapter in Book/Report/Conference proceedingChapter


In vivo microscopy (IVM) is the general term for those non-microscopic technologies that allow clinicians, pathologists and researchers to visualize or gather molecular-level information from tissues at or near the resolution of a microscope. Though the term implies that imaging may be exclusive to tissues within (or on the surface of) a living organism, numerous ex vivo applications exist. This chapter will address both in and ex vivo applications of this technology, as well as the basic principles underpinning those devices in clinical and investigational use today, with a focus on matters most pertinent to practicing anatomic pathologists. The chapter will also comment on the emerging nature of the field and the importance of involving pathology in driving such a change, and provide resources for additional exploration and learning.

Original languageEnglish (US)
Title of host publicationDigital Pathology
Subtitle of host publicationHistorical Perspectives, Current Concepts Future Applications
PublisherSpringer International Publishing
Number of pages13
ISBN (Electronic)9783319203799
ISBN (Print)9783319203782
StatePublished - Jan 1 2016


  • Anatomic pathology
  • Confocal microscopy
  • Digital pathology
  • Endoscope-based CLE (eCLE)
  • Ex vivo
  • In vivo microscopy
  • MPM
  • OCT
  • Probe-based CLE (pCLE)

ASJC Scopus subject areas

  • General Medicine


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