In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe

Jun Zhou; Guiyang Hao; Hong Weng; Yi Ting Tsai; David W. Baker; Xiankai Sun; Liping Tang

doi:10.1016/j.bmcl.2013.02.004

In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe

Jun Zhou, Guiyang Hao, Hong Weng, Yi Ting Tsai, David W. Baker, Xiankai Sun, Liping Tang

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

To image implant-surrounding activated macrophages, a macrophage-specific PET probe was prepared by conjugating folic acid (FA) and 2,2′,2″, 2‴-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetracetic acid (DOTA) to polyethylene glycol (PEG) and then labeling the conjugate with Ga-68. In vivo PET imaging evaluations demonstrate that the probe is able to detect foreign body reactions, and more importantly, quantify the degree of inflammatory responses to an implanted medical device. These results were further validated by histological analysis.

Original language	English (US)
Pages (from-to)	2044-2047
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2013.02.004
State	Published - Apr 1 2013

Keywords

Biocompatibility
Biomaterial implant
Folic acid
Inflammation
PET imaging

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2013.02.004

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title = "In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe",

abstract = "To image implant-surrounding activated macrophages, a macrophage-specific PET probe was prepared by conjugating folic acid (FA) and 2,2′,2″, 2‴-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetracetic acid (DOTA) to polyethylene glycol (PEG) and then labeling the conjugate with Ga-68. In vivo PET imaging evaluations demonstrate that the probe is able to detect foreign body reactions, and more importantly, quantify the degree of inflammatory responses to an implanted medical device. These results were further validated by histological analysis.",

keywords = "Biocompatibility, Biomaterial implant, Folic acid, Inflammation, PET imaging",

author = "Jun Zhou and Guiyang Hao and Hong Weng and Tsai, {Yi Ting} and Baker, {David W.} and Xiankai Sun and Liping Tang",

note = "Funding Information: The research was supported by NIH Grants EB007271 , EB014404 (L.T.) and U24 CA126608 (X.S.). The authors acknowledge the generous support of a private donor that allowed the purchase of the Siemens Inveon PET-CT Multi-modality System. ",

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doi = "10.1016/j.bmcl.2013.02.004",

language = "English (US)",

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AU - Zhou, Jun

AU - Hao, Guiyang

AU - Weng, Hong

AU - Tsai, Yi Ting

AU - Baker, David W.

AU - Sun, Xiankai

AU - Tang, Liping

N1 - Funding Information: The research was supported by NIH Grants EB007271 , EB014404 (L.T.) and U24 CA126608 (X.S.). The authors acknowledge the generous support of a private donor that allowed the purchase of the Siemens Inveon PET-CT Multi-modality System.

PY - 2013/4/1

Y1 - 2013/4/1

N2 - To image implant-surrounding activated macrophages, a macrophage-specific PET probe was prepared by conjugating folic acid (FA) and 2,2′,2″, 2‴-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetracetic acid (DOTA) to polyethylene glycol (PEG) and then labeling the conjugate with Ga-68. In vivo PET imaging evaluations demonstrate that the probe is able to detect foreign body reactions, and more importantly, quantify the degree of inflammatory responses to an implanted medical device. These results were further validated by histological analysis.

AB - To image implant-surrounding activated macrophages, a macrophage-specific PET probe was prepared by conjugating folic acid (FA) and 2,2′,2″, 2‴-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetracetic acid (DOTA) to polyethylene glycol (PEG) and then labeling the conjugate with Ga-68. In vivo PET imaging evaluations demonstrate that the probe is able to detect foreign body reactions, and more importantly, quantify the degree of inflammatory responses to an implanted medical device. These results were further validated by histological analysis.

KW - Biocompatibility

KW - Biomaterial implant

KW - Folic acid

KW - Inflammation

KW - PET imaging

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ER -

In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe

Abstract

Keywords

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