In vivo detection of gold nanoshells in tumors using diffuse optical spectroscopy

Raiyan T. Zaman, Parmeswaran Diagaradjane, James C. Wang, Jon Schwartz, Narasimhan Rajaram, Kelly L. Gill-Sharp, Sang H. Cho, Henry Grady Rylander, J. Donald Payne, Sunil Krishnan, James W. Tunnell

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


This study demonstrates the use of diffuse optical spectroscopy (DOS) for the noninvasive measurement of gold nanoshell concentrations in tumors of live mice. We measured the diffuse optical spectra (500800 nm) using an optical fiber probe placed in contact with the tissue surface. We performed in vitro studies on tissue phantoms illustrating an accurate measurement of goldsilica nanoshell concentration within 12.6% of the known concentration. In vivo studies were performed on a mouse xenograft tumor model. DOS spectra were measured at preinjection, immediately postinjection, 1 and 24 h postinjection times, and the nanoshell concentrations were verified using neutron activation analysis.

Original languageEnglish (US)
Pages (from-to)1715-1720
Number of pages6
JournalIEEE Journal on Selected Topics in Quantum Electronics
Issue number6
StatePublished - Nov 2007
Externally publishedYes


  • Contrast agents
  • Diffuse optical spectroscopy (DOS)
  • Diffusion theory
  • Gold nanoparticles
  • Optical imaging

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering


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