Abstract
This study demonstrates the use of diffuse optical spectroscopy (DOS) for the noninvasive measurement of gold nanoshell concentrations in tumors of live mice. We measured the diffuse optical spectra (500800 nm) using an optical fiber probe placed in contact with the tissue surface. We performed in vitro studies on tissue phantoms illustrating an accurate measurement of goldsilica nanoshell concentration within 12.6% of the known concentration. In vivo studies were performed on a mouse xenograft tumor model. DOS spectra were measured at preinjection, immediately postinjection, 1 and 24 h postinjection times, and the nanoshell concentrations were verified using neutron activation analysis.
Original language | English (US) |
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Pages (from-to) | 1715-1720 |
Number of pages | 6 |
Journal | IEEE Journal on Selected Topics in Quantum Electronics |
Volume | 13 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2007 |
Externally published | Yes |
Keywords
- Contrast agents
- Diffuse optical spectroscopy (DOS)
- Diffusion theory
- Gold nanoparticles
- Optical imaging
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electrical and Electronic Engineering