In vivo comparison of fourier-domain optical coherence tomography and intravascular ultrasonography

BACKGROUND: We sought to evaluate the findings of Fourier-domain optical coherence tomography (FD-OCT) and intravascular ultrasonography (IVUS) used for the in vivo assessment of coronary lesions. METHODS: We identified 19 lesions in 15 patients undergoing percutaneous coronary intervention that were assessed by both FD-OCT and IVUS and compared the lumen area and maximum/minimum lumen diameter at the site of maximum stenosis and the proximal and distal reference cross-sections. RESULTS: At the site of maximum stenosis, excellent correlation was found between FD-OCT and IVUS measurements: minimum lumen area (3.80 ± 2.36 mm ² and 4.60 ± 2.13 mm ², respectively; P=.002; Spearman's = 0.94), maximum lumen diameter (2.30 ± 0.79 mm ² and 2.54 ± 0.60 mm ², respectively; P=.005; Spearman's = 0.93), and minimum lumen diameter (1.89 ± 0.69 mm ² and 2.24 ± 0.54 mm ², respectively; P=.0001; Spearman's = 0.90). Weaker correlations were found between FD-OCT and IVUS measurements of the proximal reference lumen area (4.74 ± 1.86 mm ² and 5.16 ± 2.10 mm ², respectively; P=.33; Spearman's = 0.76) and distal reference lumen area (5.14 ± 1.60 mm ² and 5.47 ± 2.45 mm ², respectively; P=.144; Spearman's = 0.72). CONCLUSIONS: Excellent correlation was found in FD-OCT and IVUS luminal measurements at the site of maximum coronary stenosis with weaker correlation at the proximal and distal reference cross-sections. FD-OCT minimum lumen area measurements were smaller than the IVUS measurements.