Imparting multivalency to a bifunctional chelator: A scaffold design for targeted PET imaging probes

Wei Liu; Guiyang Hao; Michael A. Long; Tiffani Anthony; Jer Tsong Hsieh; Xiankai Sun

doi:10.1002/anie.200903556

Imparting multivalency to a bifunctional chelator: A scaffold design for targeted PET imaging probes

Wei Liu, Guiyang Hao, Michael A. Long, Tiffani Anthony, Jer Tsong Hsieh, Xiankai Sun

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Two are better than one: Multivalent scaffolds for targeted PET imaging probes not only feature chelators that form stable and neutral complexes with a radiometal but also contain functional groups for presentation of multiple targeting molecules. A bivalent scaffold was synthesized and coupled with a targeting ligand to afford the probe, which was used to efficiently image tumors in vivo (see picture).

Original language	English (US)
Pages (from-to)	7346-7349
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	40
DOIs	https://doi.org/10.1002/anie.200903556
State	Published - Sep 21 2009

Keywords

Chelates
Imaging agents
Multivalent effect
Radiochemistry

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200903556

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abstract = "Two are better than one: Multivalent scaffolds for targeted PET imaging probes not only feature chelators that form stable and neutral complexes with a radiometal but also contain functional groups for presentation of multiple targeting molecules. A bivalent scaffold was synthesized and coupled with a targeting ligand to afford the probe, which was used to efficiently image tumors in vivo (see picture).",

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AU - Anthony, Tiffani

AU - Hsieh, Jer Tsong

AU - Sun, Xiankai

PY - 2009/9/21

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KW - Imaging agents

KW - Multivalent effect

KW - Radiochemistry

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Imparting multivalency to a bifunctional chelator: A scaffold design for targeted PET imaging probes

Abstract

Keywords

ASJC Scopus subject areas

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