TY - JOUR
T1 - Impaired Thermoregulatory Function during Dynamic Exercise in Multiple Sclerosis
AU - Allen, Dustin R.
AU - Huang, Mu
AU - Morris, Nathan B.
AU - Chaseling, Georgia K.
AU - Frohman, Elliot M.
AU - Jay, Ollie
AU - Davis, Scott L.
N1 - Funding Information:
Individuals with MS are at a greater risk for thermoregulatory dysfunction and thus more vulnerable to exaggerated elevations in body temperature (internal and/or skin) than disease free individuals. Although our results indicate that individuals with MS are able to achieve a steady-state T core and LSR in the exercise intensity and environmental conditions chosen for this study, WBSL values as well as sweating thermosensitivity were significantly blunted in those with MS compared with CON. Taken together, it appears individuals with MS can achieve a thermal steady state to exercise intensities of a modest heat load; however, there is evidence that this ability may reach its capacity before the healthy population. Given the prevalence of Uhthoff’s phenomenon among this population, it is imperative that more research is done to define the limits of compensability in this population, as well as to identify ways to mitigate the risks of excessive heating during physical activity in MS. The considerable time and effort of the subjects are greatly appreciated. This study was supported by National Heart, Lung, and Blood Institute grant R15-HL-117224 (S. L. Davis); National Multiple Sclerosis Society grants RG4043A1/1 and RG4696A3/2 (S. L. Davis); MS Research Australia Incubator grant 14-009 (O. Jay and S. L. Davis); MS Research Australia Postgraduate Fellowship 15-087 (G. K. Chaseling); and the Kuzell Institute (S. L. Davis and O. Jay). No conflicts of interest, financial or otherwise, are declared by the authors. The results of this study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. The results and conclusions of the study do not constitute endorsement by the American College of Sports Medicine.
Publisher Copyright:
© 2019 by the American College of Sports Medicine.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Introduction Impairments in sudomotor function during passive whole-body heating have been reported in multiple sclerosis (MS), a demyelinating disease of the CNS that disrupts autonomic function. However, the capability of the thermoregulatory system to control body temperature during exercise has never been assessed in MS. Thus, the aim of the present study was to test the hypothesis that thermoregulatory function is impaired in MS patients compared with healthy controls (CON) exercising at similar rates of metabolic heat production. Methods Sweating and skin blood flow responses were compared between 12 individuals diagnosed with relapsing-remitting MS (9 females, 3 males) and 12 sex-, age-, mass-, and BSA-matched CON during a single bout of cycling exercise (rate of metabolic heat production: ∼4.5 W·kg -1 ) for 60 min in a climate-controlled room (25°C, 30% RH). Results Individuals with MS exhibited an attenuated increase in cumulative whole-body sweat loss after 30 min (MS, 72 ± 51 g; CON, 104 ± 37 g; P = 0.04) and 60 min (MS, 209 ± 94 g; CON, 285 ± 62 g; P = 0.02), as well as lower sweating thermosensitivity (MS, 0.49 ± 0.26 mg·cm -2 ·min -1 ·°C -1 ; CON, 0.86 ± 0.30 mg·cm -2 ·min -1 ·°C -1 ; P = 0.049). Despite evidence for thermoregulatory dysfunction, there were no differences between MS and CON in esophageal or rectal temperatures at 30-or 60-min time points (P > 0.05). Cutaneous vasculature responses were also not different in MS compared with CON (P > 0.05). Conclusion Taken together, MS blunts sweating responses during exercise while cutaneous vasculature responses are preserved. Altered mechanisms of body temperature regulation in persons with MS may lead to temporary worsening of disease symptoms and limit exercise tolerance under more thermally challenging conditions.
AB - Introduction Impairments in sudomotor function during passive whole-body heating have been reported in multiple sclerosis (MS), a demyelinating disease of the CNS that disrupts autonomic function. However, the capability of the thermoregulatory system to control body temperature during exercise has never been assessed in MS. Thus, the aim of the present study was to test the hypothesis that thermoregulatory function is impaired in MS patients compared with healthy controls (CON) exercising at similar rates of metabolic heat production. Methods Sweating and skin blood flow responses were compared between 12 individuals diagnosed with relapsing-remitting MS (9 females, 3 males) and 12 sex-, age-, mass-, and BSA-matched CON during a single bout of cycling exercise (rate of metabolic heat production: ∼4.5 W·kg -1 ) for 60 min in a climate-controlled room (25°C, 30% RH). Results Individuals with MS exhibited an attenuated increase in cumulative whole-body sweat loss after 30 min (MS, 72 ± 51 g; CON, 104 ± 37 g; P = 0.04) and 60 min (MS, 209 ± 94 g; CON, 285 ± 62 g; P = 0.02), as well as lower sweating thermosensitivity (MS, 0.49 ± 0.26 mg·cm -2 ·min -1 ·°C -1 ; CON, 0.86 ± 0.30 mg·cm -2 ·min -1 ·°C -1 ; P = 0.049). Despite evidence for thermoregulatory dysfunction, there were no differences between MS and CON in esophageal or rectal temperatures at 30-or 60-min time points (P > 0.05). Cutaneous vasculature responses were also not different in MS compared with CON (P > 0.05). Conclusion Taken together, MS blunts sweating responses during exercise while cutaneous vasculature responses are preserved. Altered mechanisms of body temperature regulation in persons with MS may lead to temporary worsening of disease symptoms and limit exercise tolerance under more thermally challenging conditions.
KW - AUTONOMIC DYSFUNCTION
KW - PHYSICAL ACTIVITY
KW - SKIN BLOOD FLOW
KW - SWEAT RATE
KW - THERMOSENSITIVITY
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U2 - 10.1249/MSS.0000000000001821
DO - 10.1249/MSS.0000000000001821
M3 - Article
C2 - 30779715
AN - SCOPUS:85061672944
SN - 0195-9131
VL - 51
SP - 395
EP - 404
JO - Medicine and science in sports and exercise
JF - Medicine and science in sports and exercise
IS - 3
ER -