Impaired insulin signaling in the B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ mouse model of complement factor 5 deficiency

Keyphrases

• Mouse Model 100%
• Complement Component 5 100%
• Impaired Insulin Secretion 100%
• Factor V Deficiency 100%
• High-fat Diet 20%
• Adipose Tissue 20%
• Insulin Receptor 20%
• Adenoviral Delivery 20%
• Whole Genome Sequencing 10%
• Metabolic Phenotype 10%
• Innate Immune Response 10%
• Insulin Sensitivity 10%
• Insulin Action 10%
• Peripheral Insulin Resistance 10%
• Genetic Defects 10%
• Receptor-interacting Protein Kinase 1 (RIPK1) 10%
• Liver Tissue 10%
• Chemoattractant 10%
• Glucose Intolerance 10%
• Liver Lipid 10%
• Obese Mice 10%
• Proinsulin 10%
• Factor V Gene 10%
• Metabolic Effects 10%
• Inflammatory Phenotype 10%
• Decreased Expression 10%
• Adipose Tissue Inflammation 10%
• InsR 10%
• Liver Mass 10%
• Insulin Receptor Gene 10%
• Low Fat 10%
• Processing Defects 10%
• Systemic Metabolism 10%
• System Impact 10%

Immunology and Microbiology

• Mouse Model 100%
• Insulin Signaling 100%
• Complement Component 5 100%
• Mouse 50%
• Adipose Tissue 30%
• Insulin Receptor 30%
• Insulin Resistance 10%
• Innate Immune System 10%
• Mouse Mutant 10%
• Receptor Gene 10%
• Insulin Sensitivity 10%
• Chemoattractant 10%
• Liver Tissue 10%
• Whole Genome Sequencing 10%

Biochemistry, Genetics and Molecular Biology

• Insulin Signaling 100%
• Mouse Model 100%
• Complement Component 5 100%
• Mouse 50%
• Insulin Receptor 30%
• Whole Genome Sequencing 10%
• Genetics 10%
• Metabolic Pathway 10%
• Insulin Resistance 10%
• Receptor Gene 10%
• Triglyceride 10%
• Insulin Sensitivity 10%
• Innate Immunity 10%
• Mouse Mutant 10%
• Proinsulin 10%