TY - JOUR
T1 - Impact of smoking during pregnancy on functional coagulation testing
AU - Dizon-Townson, Donna
AU - Miller, Connie
AU - Momirova, Valerija
AU - Sibai, Baha
AU - Spong, Catheriney
AU - Wendel, George
AU - Wenstrom, Katharine
AU - Samuels, Philip
AU - Caritis, Steve
AU - Sorokin, Yoram
AU - Miodovnik, Menachem
AU - O'Sullivan, Maryj
AU - Conway, Deborah
AU - Wapner, Ronaldj
AU - Gabbe, Steveng
PY - 2012
Y1 - 2012
N2 - Compounds that are systemically absorbed during the course of cigarette smoking, and their metabolites, affect the coagulation system and cause endothelial dysfunction, dyslipidemia, and platelet activation leading to a prothrombotic state. In addition, smoking increases the activity of fibrinogen, homocysteine, and C-reactive protein. We hypothesize that smoking may affect functional coagulation testing during pregnancy. A secondary analysis of 371 women pregnant with a singleton pregnancy and enrolled in a multicenter, prospective observational study of complications of factor V Leiden mutation subsequently underwent functional coagulation testing for antithrombin III, protein C antigen and activity, and protein S antigen and activity. Smoking was assessed by self-report at time of enrollment (<14 weeks). None of the functional coagulation testing results was altered by maternal smoking during pregnancy. Smoking does not affect the aforementioned functional coagulation testing results during pregnancy.
AB - Compounds that are systemically absorbed during the course of cigarette smoking, and their metabolites, affect the coagulation system and cause endothelial dysfunction, dyslipidemia, and platelet activation leading to a prothrombotic state. In addition, smoking increases the activity of fibrinogen, homocysteine, and C-reactive protein. We hypothesize that smoking may affect functional coagulation testing during pregnancy. A secondary analysis of 371 women pregnant with a singleton pregnancy and enrolled in a multicenter, prospective observational study of complications of factor V Leiden mutation subsequently underwent functional coagulation testing for antithrombin III, protein C antigen and activity, and protein S antigen and activity. Smoking was assessed by self-report at time of enrollment (<14 weeks). None of the functional coagulation testing results was altered by maternal smoking during pregnancy. Smoking does not affect the aforementioned functional coagulation testing results during pregnancy.
KW - coagulation
KW - factor V Leiden
KW - pregnancy
KW - smoking
UR - http://www.scopus.com/inward/record.url?scp=84863399438&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863399438&partnerID=8YFLogxK
U2 - 10.1055/s-0031-1285097
DO - 10.1055/s-0031-1285097
M3 - Article
C2 - 21818732
AN - SCOPUS:84863399438
SN - 0735-1631
VL - 29
SP - 225
EP - 230
JO - American Journal of Perinatology
JF - American Journal of Perinatology
IS - 3
ER -