Impact of smoking during pregnancy on functional coagulation testing

Donna Dizon-Townson, Connie Miller, Valerija Momirova, Baha Sibai, Catheriney Spong, George Wendel, Katharine Wenstrom, Philip Samuels, Steve Caritis, Yoram Sorokin, Menachem Miodovnik, Maryj O'Sullivan, Deborah Conway, Ronaldj Wapner, Steveng Gabbe

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Compounds that are systemically absorbed during the course of cigarette smoking, and their metabolites, affect the coagulation system and cause endothelial dysfunction, dyslipidemia, and platelet activation leading to a prothrombotic state. In addition, smoking increases the activity of fibrinogen, homocysteine, and C-reactive protein. We hypothesize that smoking may affect functional coagulation testing during pregnancy. A secondary analysis of 371 women pregnant with a singleton pregnancy and enrolled in a multicenter, prospective observational study of complications of factor V Leiden mutation subsequently underwent functional coagulation testing for antithrombin III, protein C antigen and activity, and protein S antigen and activity. Smoking was assessed by self-report at time of enrollment (<14 weeks). None of the functional coagulation testing results was altered by maternal smoking during pregnancy. Smoking does not affect the aforementioned functional coagulation testing results during pregnancy.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalAmerican Journal of Perinatology
Issue number3
StatePublished - 2012
Externally publishedYes


  • coagulation
  • factor V Leiden
  • pregnancy
  • smoking

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


Dive into the research topics of 'Impact of smoking during pregnancy on functional coagulation testing'. Together they form a unique fingerprint.

Cite this