Impact of estrogens and estrogen receptor-α in brain lipid metabolism

Eugenia Morselli, Roberta de Souza Santos, Su Gao, Yenniffer Ávalos, Alfredo Criollo, Biff F. Palmer, Deborah J. Clegg

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Estrogens and their receptors play key roles in regulating body weight, energy expenditure, and metabolic homeostasis. It is known that lack of estrogens promotes increased food intake and induces the expansion of adipose tissues, for which much is known. An area of estrogenic research that has received less attention is the role of estrogens and their receptors in influencing intermediary lipid metabolism in organs such as the brain. In this review, we highlight the actions of estrogens and their receptors in regulating their impact on modulating fatty acid content, utilization, and oxidation through their direct impact on intracellular signaling cascades within the central nervous system.

Original languageEnglish (US)
Pages (from-to)E7-E14
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number1
StatePublished - Jul 2018


  • Alzheimer’s disease
  • Estrogens
  • Fatty acid oxidation
  • Fatty acids
  • Sexual dimorphism

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)


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