Impact of Additional Anomalies on Postnatal Outcomes in Congenital Lung Malformations

Juan C. Reyna, Jessica A. Zagory, Sushmita Yallapragada, Patricia Santiago-Munoz, David T. Schindel

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Approximately 20% of fetuses diagnosed with congenital lung malformations (CLMs) are found to have additional anomalies. We aim to determine if additional anomalies have an impact on postnatal outcomes for patients with CLMs. Methods: After institutional review board approval, we performed a retrospective review of live-born patients with CLMs from 2008 to 2018. All patients were prenatally diagnosed with CLMs. Clinical information pertaining to additional congenital anomalies and outcomes was collected from the electronic health record and analyzed. Results: Of the 88 patients who had a prenatal diagnosis of CLMs, 20.5% had additional anomalies. Ten of the 18 patients (56%) were considered to have a major anomaly in addition to CLMs. Outcomes for patients electing nonoperative management of CLMs were similar between those with and without an additional anomaly. Although patients with an additional anomaly were more likely to have perinatal respiratory complications (44% versus 17%, P = 0.03), the number of preoperative clinic and emergency department visits, age at surgery, minimally invasive approach to surgical resection of CLM, estimated blood loss, length of hospital stay, intubation, duration of intubation, 30-day postoperative complications, and long term sequelae were not statistically different. This held true when stratified for major versus minor anomalies. Conclusions: Twenty percent of fetuses diagnosed with CLM in our population have additional anomalies. Newborns with additional anomalies have a higher risk of pre-excision pulmonary complications. However, the overall outcomes of all patients with CLMs are similar.

Original languageEnglish (US)
Pages (from-to)611-617
Number of pages7
JournalJournal of Surgical Research
StatePublished - Dec 2020


  • Congenital anomaly
  • Congenital lung malformation
  • Congenital pulmonary airway malformation
  • Outcomes
  • Surgery

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Impact of Additional Anomalies on Postnatal Outcomes in Congenital Lung Malformations'. Together they form a unique fingerprint.

Cite this