Impact of 13(S)-HPODE, a lipoxygenase product of linoleic acid, on calcium transport and Na,K-ATPase activity in the myocardial sarcolemma

G. A. Cherednichenko; A. A. Moibenko; I. A. Butovich; S. A. Ogii

doi:10.1007/BF02445008

Impact of 13(S)-HPODE, a lipoxygenase product of linoleic acid, on calcium transport and Na,K-ATPase activity in the myocardial sarcolemma

G. A. Cherednichenko, A. A. Moibenko, I. A. Butovich, S. A. Ogii

Research output: Contribution to journal › Article › peer-review

Abstract

In this in vitro study using a purified sarcolemmic fraction of guinea pig myocardium, the 13(S)-hydroperoxide of linoleic acid (13-HPODE) increased in a dose-dependent manner the permeability of myocardial sarcolemma to Ca ions in concentrations above 10 μmol/liter, stimulated Na/Ca exchange there in concentrations from 0.1 to 10 μmol/liter, and exerted a digitalis-like action on sarcolemmic Na,K-ATPase in concentrations between 0.1 and 100 μmol/liter (IC₅₀=20 μmol/liter). The results indicate that the linoleic acid hydroperoxide may be an effective modulator of sarcolemmic Ca²⁺ transport and of membrane-bound enzymes.

Original language	English (US)
Pages (from-to)	895-897
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	120
Issue number	3
DOIs	https://doi.org/10.1007/BF02445008
State	Published - 1995

Keywords

Ca transport
hydroperoxylinoleic acid
Na,K-ATPase
sarcolemma

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/BF02445008

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title = "Impact of 13(S)-HPODE, a lipoxygenase product of linoleic acid, on calcium transport and Na,K-ATPase activity in the myocardial sarcolemma",

abstract = "In this in vitro study using a purified sarcolemmic fraction of guinea pig myocardium, the 13(S)-hydroperoxide of linoleic acid (13-HPODE) increased in a dose-dependent manner the permeability of myocardial sarcolemma to Ca ions in concentrations above 10 μmol/liter, stimulated Na/Ca exchange there in concentrations from 0.1 to 10 μmol/liter, and exerted a digitalis-like action on sarcolemmic Na,K-ATPase in concentrations between 0.1 and 100 μmol/liter (IC50=20 μmol/liter). The results indicate that the linoleic acid hydroperoxide may be an effective modulator of sarcolemmic Ca2+ transport and of membrane-bound enzymes.",

keywords = "Ca transport, hydroperoxylinoleic acid, Na,K-ATPase, sarcolemma",

author = "Cherednichenko, {G. A.} and Moibenko, {A. A.} and Butovich, {I. A.} and Ogii, {S. A.}",

year = "1995",

doi = "10.1007/BF02445008",

language = "English (US)",

volume = "120",

pages = "895--897",

journal = "Bulletin of Experimental Biology and Medicine",

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TY - JOUR

T1 - Impact of 13(S)-HPODE, a lipoxygenase product of linoleic acid, on calcium transport and Na,K-ATPase activity in the myocardial sarcolemma

AU - Cherednichenko, G. A.

AU - Moibenko, A. A.

AU - Butovich, I. A.

AU - Ogii, S. A.

PY - 1995

Y1 - 1995

N2 - In this in vitro study using a purified sarcolemmic fraction of guinea pig myocardium, the 13(S)-hydroperoxide of linoleic acid (13-HPODE) increased in a dose-dependent manner the permeability of myocardial sarcolemma to Ca ions in concentrations above 10 μmol/liter, stimulated Na/Ca exchange there in concentrations from 0.1 to 10 μmol/liter, and exerted a digitalis-like action on sarcolemmic Na,K-ATPase in concentrations between 0.1 and 100 μmol/liter (IC50=20 μmol/liter). The results indicate that the linoleic acid hydroperoxide may be an effective modulator of sarcolemmic Ca2+ transport and of membrane-bound enzymes.

AB - In this in vitro study using a purified sarcolemmic fraction of guinea pig myocardium, the 13(S)-hydroperoxide of linoleic acid (13-HPODE) increased in a dose-dependent manner the permeability of myocardial sarcolemma to Ca ions in concentrations above 10 μmol/liter, stimulated Na/Ca exchange there in concentrations from 0.1 to 10 μmol/liter, and exerted a digitalis-like action on sarcolemmic Na,K-ATPase in concentrations between 0.1 and 100 μmol/liter (IC50=20 μmol/liter). The results indicate that the linoleic acid hydroperoxide may be an effective modulator of sarcolemmic Ca2+ transport and of membrane-bound enzymes.

KW - Ca transport

KW - hydroperoxylinoleic acid

KW - Na,K-ATPase

KW - sarcolemma

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DO - 10.1007/BF02445008

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SP - 895

EP - 897

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

IS - 3

ER -

Impact of 13(S)-HPODE, a lipoxygenase product of linoleic acid, on calcium transport and Na,K-ATPase activity in the myocardial sarcolemma

Abstract

Keywords

ASJC Scopus subject areas

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