Immunotherapy for allergic fungal sinusitis: Three years' experience

R. L. Mabry, B. F. Marple, R. J. Folker, C. S. Mabry

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


Since August 1994, we have treated patients with histologically proven allergic fungal sinusitis with surgery followed by immunotherapy, employing fungal and nonfungal antigens to which hypersensitivity has been demonstrated. Our results continue to be encouraging. Not only have we encountered no indication that fungal immunotherapy has worsened these patients' condition or caused a recurrence of disease, we have confirmed dramatic improvement in these patients compared with the generally accepted course of this disease. Of 11 patients who have received immunotherapy for 1 to 3 years (mean 28 months), none has required regular or frequent treatment with a single brief course of systemic steroids, and only three are receiving topical nasal steroids. No repeat surgeries for recurrent allergic fungal sinusitis have been required in the treatment group. This combination of surgery and immunotherapy has continued to prove beneficial, and we urge others to consider this approach to therapy.

Original languageEnglish (US)
Pages (from-to)648-651
Number of pages4
JournalOtolaryngology - Head and Neck Surgery
Issue number6
StatePublished - 1998

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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