Immunosuppression-induced leukoencephalopathy from tacrolimus (FK506)

Steven L. Small, Melanie B. Fukui, Gregory T. Bramblett, Benjamin H. Eidelman

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Tacrolimus (FK506) has recently been approved for immunosuppression in organ transplantation, although its use is accompanied by a wide spectrum of neurotoxic side effects. We describe the clinical, radiological, and pathological features of 3 cases of tacrolimus-related leukoencephalopathy. The syndrome of immunosuppression-related leukoencephalopathy is proposed as an uncommon neurological syndrome occurring in patients with organ transplants involving demyelination, in particular in the parieto-occipital region and centrum semiovale. Although the syndrome is not associated with a particular (absolute) serum level of tacrolimus, it resolves spontaneously upon decreasing the dose. The tacrolimus-related syndrome has a similar radiographic and pathologic appearance as the analogous syndrome that occurs in patients taking cyclosporine.

Original languageEnglish (US)
Pages (from-to)575-580
Number of pages6
JournalAnnals of Neurology
Issue number4
StatePublished - Oct 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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