IMMUNOPROTECTION OF RATS AGAINST HAEMOPHILUS INFLUENZAE TYPE B DISEASE MEDIATED BY MONOCLONAL ANTIBODY AGAINST A HAEMOPHILUS OUTER-MEMBRANE PROTEIN

EricJ Hansen; PaulA Gulig; StellaM Robertson; CarolynF Frisch; ElizabethJ Haanes

doi:10.1016/S0140-6736(82)91394-0

IMMUNOPROTECTION OF RATS AGAINST HAEMOPHILUS INFLUENZAE TYPE B DISEASE MEDIATED BY MONOCLONAL ANTIBODY AGAINST A HAEMOPHILUS OUTER-MEMBRANE PROTEIN

EricJ Hansen, PaulA Gulig, StellaM Robertson, CarolynF Frisch, ElizabethJ Haanes

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Abstract

Infant rats passively immunised with a murine monoclonal antibody against a cell-surface-exposed outer-membrane protein of Haemophilus influenzae type b (Hib) were protected against systemic Hib disease induced by intraperitoneal injection of virulent Hib cells. The immunoprotection mediated by this monoclonal antibody was specific for Hib strains carrying the protein antigenic determinant that it recognised; the antibody gave no protection against disease when passively immunised animals were challenged with a heterologous Hib strain. The immunoprotection given by an antibody against a Hib outer-membrane protein suggests that Hib outer-membrane proteins have potential for development as Hib vaccines.

Original language	English (US)
Pages (from-to)	366-368
Number of pages	3
Journal	The Lancet
Volume	319
Issue number	8268
DOIs	https://doi.org/10.1016/S0140-6736(82)91394-0
State	Published - Feb 13 1982

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Medicine(all)

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title = "IMMUNOPROTECTION OF RATS AGAINST HAEMOPHILUS INFLUENZAE TYPE B DISEASE MEDIATED BY MONOCLONAL ANTIBODY AGAINST A HAEMOPHILUS OUTER-MEMBRANE PROTEIN",

abstract = "Infant rats passively immunised with a murine monoclonal antibody against a cell-surface-exposed outer-membrane protein of Haemophilus influenzae type b (Hib) were protected against systemic Hib disease induced by intraperitoneal injection of virulent Hib cells. The immunoprotection mediated by this monoclonal antibody was specific for Hib strains carrying the protein antigenic determinant that it recognised; the antibody gave no protection against disease when passively immunised animals were challenged with a heterologous Hib strain. The immunoprotection given by an antibody against a Hib outer-membrane protein suggests that Hib outer-membrane proteins have potential for development as Hib vaccines.",

author = "EricJ Hansen and PaulA Gulig and StellaM Robertson and CarolynF Frisch and ElizabethJ Haanes",

note = "Funding Information: This study was supported by the National Institutes of Health (grant no. AI-17621).",

year = "1982",

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doi = "10.1016/S0140-6736(82)91394-0",

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AU - Hansen, EricJ

AU - Gulig, PaulA

AU - Robertson, StellaM

AU - Frisch, CarolynF

AU - Haanes, ElizabethJ

N1 - Funding Information: This study was supported by the National Institutes of Health (grant no. AI-17621).

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AB - Infant rats passively immunised with a murine monoclonal antibody against a cell-surface-exposed outer-membrane protein of Haemophilus influenzae type b (Hib) were protected against systemic Hib disease induced by intraperitoneal injection of virulent Hib cells. The immunoprotection mediated by this monoclonal antibody was specific for Hib strains carrying the protein antigenic determinant that it recognised; the antibody gave no protection against disease when passively immunised animals were challenged with a heterologous Hib strain. The immunoprotection given by an antibody against a Hib outer-membrane protein suggests that Hib outer-membrane proteins have potential for development as Hib vaccines.

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IMMUNOPROTECTION OF RATS AGAINST HAEMOPHILUS INFLUENZAE TYPE B DISEASE MEDIATED BY MONOCLONAL ANTIBODY AGAINST A HAEMOPHILUS OUTER-MEMBRANE PROTEIN

Abstract

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