Immunomodulatory and therapeutic activity of curcumin

Raghvendra M. Srivastava; Sarvjeet Singh; Shiv K. Dubey; Krishna Misra; Ashok Khar

doi:10.1016/j.intimp.2010.08.014

Immunomodulatory and therapeutic activity of curcumin

Raghvendra M. Srivastava, Sarvjeet Singh, Shiv K. Dubey, Krishna Misra, Ashok Khar

Research output: Contribution to journal › Review article › peer-review

200 Scopus citations

Abstract

Inflammation is a disease of vigorous uncontrolled activated immune responses. Overwhelming reports have suggested that the modulation of immune responses by curcumin plays a dominant role in the treatment of inflammation and metabolic diseases. Observations from both in-vitro and in-vivo studies have provided strong evidence towards the therapeutic potential of curcumin. These studies have also identified a plethora of biological targets and intricate mechanisms of action that characterize curcumin as a potent 'drug' for numerous ailments. During inflammation the functional influence of lymphocytes and the related cross-talk can be modulated by curcumin to achieve the desired immune status against diseases. This review describes the regulation of immune responses by curcumin and effectiveness of curcumin in treatment of diseases of diverse nature.

Original language	English (US)
Pages (from-to)	331-341
Number of pages	11
Journal	International Immunopharmacology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/j.intimp.2010.08.014
State	Published - Mar 1 2011

Keywords

Anti-cancerous
Anti-inflammatory
Curcumin
Immune and metabolic diseases

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

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10.1016/j.intimp.2010.08.014

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abstract = "Inflammation is a disease of vigorous uncontrolled activated immune responses. Overwhelming reports have suggested that the modulation of immune responses by curcumin plays a dominant role in the treatment of inflammation and metabolic diseases. Observations from both in-vitro and in-vivo studies have provided strong evidence towards the therapeutic potential of curcumin. These studies have also identified a plethora of biological targets and intricate mechanisms of action that characterize curcumin as a potent 'drug' for numerous ailments. During inflammation the functional influence of lymphocytes and the related cross-talk can be modulated by curcumin to achieve the desired immune status against diseases. This review describes the regulation of immune responses by curcumin and effectiveness of curcumin in treatment of diseases of diverse nature.",

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AU - Singh, Sarvjeet

AU - Dubey, Shiv K.

AU - Misra, Krishna

AU - Khar, Ashok

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Immunomodulatory and therapeutic activity of curcumin

Abstract

Keywords

ASJC Scopus subject areas

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