Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyltransferase

Dwight C. German; Gordon Bruce; Louis B. Hersh

doi:10.1016/0304-3940(85)90391-X

Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyltransferase

Dwight C. German, Gordon Bruce, Louis B. Hersh

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Abstract

Antibodies against human placental choline acetyltransferase (ChAT) were used to immunohistochemically stain cholinergic neurons in the neostriatum and nucleus basalis of Meynert in human brain. Cells in both regions were intensely stained as were nerve fibers. Comparable cells were stained in these same brain regions in the rat. This anti-human ChAT antibody will enable the further detailed characterization of cholinergic neurons in the human brain in both health and disease.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Neuroscience letters
Volume	61
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(85)90391-X
State	Published - Oct 24 1985

Keywords

choline acetyltransferase
human brain
immunohistochemistry

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(85)90391-X

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abstract = "Antibodies against human placental choline acetyltransferase (ChAT) were used to immunohistochemically stain cholinergic neurons in the neostriatum and nucleus basalis of Meynert in human brain. Cells in both regions were intensely stained as were nerve fibers. Comparable cells were stained in these same brain regions in the rat. This anti-human ChAT antibody will enable the further detailed characterization of cholinergic neurons in the human brain in both health and disease.",

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AU - Bruce, Gordon

AU - Hersh, Louis B.

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Y1 - 1985/10/24

N2 - Antibodies against human placental choline acetyltransferase (ChAT) were used to immunohistochemically stain cholinergic neurons in the neostriatum and nucleus basalis of Meynert in human brain. Cells in both regions were intensely stained as were nerve fibers. Comparable cells were stained in these same brain regions in the rat. This anti-human ChAT antibody will enable the further detailed characterization of cholinergic neurons in the human brain in both health and disease.

AB - Antibodies against human placental choline acetyltransferase (ChAT) were used to immunohistochemically stain cholinergic neurons in the neostriatum and nucleus basalis of Meynert in human brain. Cells in both regions were intensely stained as were nerve fibers. Comparable cells were stained in these same brain regions in the rat. This anti-human ChAT antibody will enable the further detailed characterization of cholinergic neurons in the human brain in both health and disease.

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KW - human brain

KW - immunohistochemistry

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Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyltransferase

Abstract

Keywords

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