Immunobiology of age-related macular degeneration

Rafael L. Ufret-Vincenty; Sarah L. Doyle

doi:10.1016/B978-0-12-809324-5.01388-2

Immunobiology of age-related macular degeneration

Rafael L. Ufret-Vincenty, Sarah L. Doyle

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Despite recent therapeutic advances, clinical outcomes of both neovascular and atrophic age-related macular degeneration (AMD) remain suboptimal. This article reviews evidence supporting the concept that the immune system plays an important role in the pathogenesis of AMD. This includes genetic results, histopathology data, serological data, and observations in animal models. It is important to recognize the immaturity of our knowledge and the need to expand our understanding of the early pathologic events in AMD, with the goal of identifying new strategies to prevent rather than treat the disease. The immune system will likely provide new therapeutic targets.

Original language	English (US)
Title of host publication	The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
Publisher	Elsevier Science Ltd.
Pages	279-284
Number of pages	6
ISBN (Electronic)	9780128093245
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.01388-2
State	Published - Jan 1 2016

Keywords

AMD
ARMD
Age-related macular degeneration
C-reactive protein
CNV
Choroidal neovascularization
Complement factor H
Drusen
Geographic atrophy
Histopathology
Immune system
Immunopathology
Inflammation
Macrophages
NLRP3-Inflammasome
Single nucleotide polymorphism

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/B978-0-12-809324-5.01388-2

Cite this

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title = "Immunobiology of age-related macular degeneration",

abstract = "Despite recent therapeutic advances, clinical outcomes of both neovascular and atrophic age-related macular degeneration (AMD) remain suboptimal. This article reviews evidence supporting the concept that the immune system plays an important role in the pathogenesis of AMD. This includes genetic results, histopathology data, serological data, and observations in animal models. It is important to recognize the immaturity of our knowledge and the need to expand our understanding of the early pathologic events in AMD, with the goal of identifying new strategies to prevent rather than treat the disease. The immune system will likely provide new therapeutic targets.",

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AB - Despite recent therapeutic advances, clinical outcomes of both neovascular and atrophic age-related macular degeneration (AMD) remain suboptimal. This article reviews evidence supporting the concept that the immune system plays an important role in the pathogenesis of AMD. This includes genetic results, histopathology data, serological data, and observations in animal models. It is important to recognize the immaturity of our knowledge and the need to expand our understanding of the early pathologic events in AMD, with the goal of identifying new strategies to prevent rather than treat the disease. The immune system will likely provide new therapeutic targets.

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KW - C-reactive protein

KW - CNV

KW - Choroidal neovascularization

KW - Complement factor H

KW - Drusen

KW - Geographic atrophy

KW - Histopathology

KW - Immune system

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BT - The Curated Reference Collection in Neuroscience and Biobehavioral Psychology

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Immunobiology of age-related macular degeneration

Abstract

Keywords

ASJC Scopus subject areas

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