TY - JOUR
T1 - Immune checkpoint inhibitor-related myositis
T2 - From pathophysiology to treatment
AU - Sundarrajan, Chandrasekhar
AU - Bhai, Salman
AU - Dimachkie, Mazen M.
N1 - Publisher Copyright:
© Copyright CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 2023.
PY - 2023/2
Y1 - 2023/2
N2 - With rapid advances in immuno-oncology, immune checkpoint inhibitors (ICIs) are increasingly used for a broad array of malignancies. This has led to a novel spectrum of adverse effects including ICI-related myositis, a potentially life-threatening neuromuscular complication that must be diagnosed and treated promptly. Significant gaps exist in the current understanding of ICI-related myositis due to the rarity of the condition and the lack of evidence-based guidelines, prompting the need to synthesise the most relevant and recent published works in the field. This review provides a broad overview of ICI-related myositis with an emphasis on pathophysiology, epidemiology, clinical features, workup, management and future directions.
AB - With rapid advances in immuno-oncology, immune checkpoint inhibitors (ICIs) are increasingly used for a broad array of malignancies. This has led to a novel spectrum of adverse effects including ICI-related myositis, a potentially life-threatening neuromuscular complication that must be diagnosed and treated promptly. Significant gaps exist in the current understanding of ICI-related myositis due to the rarity of the condition and the lack of evidence-based guidelines, prompting the need to synthesise the most relevant and recent published works in the field. This review provides a broad overview of ICI-related myositis with an emphasis on pathophysiology, epidemiology, clinical features, workup, management and future directions.
KW - autoimmunity
KW - immune checkpoint inhibitors
KW - immunotherapy
KW - myositis
KW - neoplasms
UR - http://www.scopus.com/inward/record.url?scp=85149170756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85149170756&partnerID=8YFLogxK
U2 - 10.55563/clinexprheumatol/q7mdjs
DO - 10.55563/clinexprheumatol/q7mdjs
M3 - Review article
C2 - 36622122
AN - SCOPUS:85149170756
SN - 0392-856X
VL - 41
SP - 379
EP - 385
JO - Clinical and experimental rheumatology
JF - Clinical and experimental rheumatology
IS - 2
ER -