Imaging and quantifying drug delivery in skin – Part 1: Autoradiography and mass spectrometry imaging

Sébastien Grégoire, Gustavo S. Luengo, Philippe Hallegot, Ana Maria Pena, Xueqin Chen, Thomas Bornschlögl, Kin F. Chan, Isaac Pence, Peyman Obeidy, Amin Feizpour, Sinyoung Jeong, Conor L. Evans

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


In this two-part review we present an up-to-date description of different imaging methods available to map the localization of drugs on skin as a complement of established ex-vivo absorption studies. This first part deals with invasive methods which are grouped in two classes according to their underlying principles: i) methods using radioactivity such as autoradiography and ii) mass spectrometry methods such as MALDI and SIMS. For each method, a description of the principle is given along with example applications of imaging and quantifying drug delivery in human skin. Thanks to these techniques a better assessment of the fate of drugs is obtained: its localization on a particular skin structure, its potential accumulation, etc. A critical comparison in terms of capabilities, sensitivity and practical applicability is included that will help the reader to select the most appropriate technique depending on the particular problem to be solved.

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalAdvanced Drug Delivery Reviews
StatePublished - Jan 1 2020
Externally publishedYes


  • Autoradiography
  • Drug delivery
  • Dynamic SIMS
  • Human skin
  • Imaging
  • Static SIMS

ASJC Scopus subject areas

  • Pharmaceutical Science


Dive into the research topics of 'Imaging and quantifying drug delivery in skin – Part 1: Autoradiography and mass spectrometry imaging'. Together they form a unique fingerprint.

Cite this