TY - GEN
T1 - Image quality improvements with time-of-flight positron emission tomography for molecular imaging
AU - Manjeshwar, Ravindra M.
AU - Shao, Yiping
AU - Jansen, Floris P.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - The renewed interest in Time Of Flight (TOF) PET is being driven by the development of detector technology and the growth of new molecular imaging applications. In this study we performed Monte Carlo simulations to quantify image quality improvements as a function of timing resolution for imaging scenarios that mimic whole body and brain imaging. We implemented an iterative image reconstruction algorithm that incorporated time-of-flight information. Image quality, as measured through contrast and noise metrics, consistently improved with improved timing resolution. We simulated and compared a conventional PET scanner with a TOF-PET scanner with 200 ps timing resolution. For lesions embedded in 40cm and 20 cm cylindrical objects, lesion contrast improved by a factor of 3.4 and 2.3, respectively. TOF-PET holds the potential for significantly improved imaging over conventional PET scanners of equivalent sensitivity.
AB - The renewed interest in Time Of Flight (TOF) PET is being driven by the development of detector technology and the growth of new molecular imaging applications. In this study we performed Monte Carlo simulations to quantify image quality improvements as a function of timing resolution for imaging scenarios that mimic whole body and brain imaging. We implemented an iterative image reconstruction algorithm that incorporated time-of-flight information. Image quality, as measured through contrast and noise metrics, consistently improved with improved timing resolution. We simulated and compared a conventional PET scanner with a TOF-PET scanner with 200 ps timing resolution. For lesions embedded in 40cm and 20 cm cylindrical objects, lesion contrast improved by a factor of 3.4 and 2.3, respectively. TOF-PET holds the potential for significantly improved imaging over conventional PET scanners of equivalent sensitivity.
UR - http://www.scopus.com/inward/record.url?scp=33646777462&partnerID=8YFLogxK
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U2 - 10.1109/ICASSP.2005.1416438
DO - 10.1109/ICASSP.2005.1416438
M3 - Conference contribution
AN - SCOPUS:33646777462
SN - 0780388747
SN - 9780780388741
T3 - ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
SP - V853-V856
BT - 2005 IEEE ICASSP '05 - Proc. - Design and Implementation of Signal Proces.Syst.,Indust. Technol. Track,Machine Learning for Signal Proces. Education, Spec. Sessions
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2005 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP '05
Y2 - 18 March 2005 through 23 March 2005
ER -