Iloprost enhances survival of axial-pattern skin flaps in an ischemia-reperfusion model

U. Rajagopal; R. M. Friedman; J. B. Robinson; R. J. Rohrich

Iloprost enhances survival of axial-pattern skin flaps in an ischemia-reperfusion model

U. Rajagopal, R. M. Friedman, J. B. Robinson, R. J. Rohrich

Plastic Surgery

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Iloprost, a stable prostacyclin analogue, significantly enhances the survival of an axial-pattern groin flap in rats after ischemia-reperfusion. Treated flaps showed viability over 90 percent of their area 7 days after an 8-hour ischemic episode, whereas the saline-treated controls were viable over only 20 percent of their area (p = 0.002). This effect was seen at a low (10 ng/kg) dosage, and no ap-parent side effects were noted.

Original language	English (US)
Pages (from-to)	884-887
Number of pages	4
Journal	Plastic and reconstructive surgery
Volume	95
Issue number	4
State	Published - Apr 1995

ASJC Scopus subject areas

Surgery

Cite this

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title = "Iloprost enhances survival of axial-pattern skin flaps in an ischemia-reperfusion model",

abstract = "Iloprost, a stable prostacyclin analogue, significantly enhances the survival of an axial-pattern groin flap in rats after ischemia-reperfusion. Treated flaps showed viability over 90 percent of their area 7 days after an 8-hour ischemic episode, whereas the saline-treated controls were viable over only 20 percent of their area (p = 0.002). This effect was seen at a low (10 ng/kg) dosage, and no ap-parent side effects were noted.",

author = "U. Rajagopal and Friedman, {R. M.} and Robinson, {J. B.} and Rohrich, {R. J.}",

year = "1995",

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language = "English (US)",

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T1 - Iloprost enhances survival of axial-pattern skin flaps in an ischemia-reperfusion model

AU - Rajagopal, U.

AU - Friedman, R. M.

AU - Robinson, J. B.

AU - Rohrich, R. J.

PY - 1995/4

Y1 - 1995/4

N2 - Iloprost, a stable prostacyclin analogue, significantly enhances the survival of an axial-pattern groin flap in rats after ischemia-reperfusion. Treated flaps showed viability over 90 percent of their area 7 days after an 8-hour ischemic episode, whereas the saline-treated controls were viable over only 20 percent of their area (p = 0.002). This effect was seen at a low (10 ng/kg) dosage, and no ap-parent side effects were noted.

AB - Iloprost, a stable prostacyclin analogue, significantly enhances the survival of an axial-pattern groin flap in rats after ischemia-reperfusion. Treated flaps showed viability over 90 percent of their area 7 days after an 8-hour ischemic episode, whereas the saline-treated controls were viable over only 20 percent of their area (p = 0.002). This effect was seen at a low (10 ng/kg) dosage, and no ap-parent side effects were noted.

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M3 - Article

C2 - 7535936

AN - SCOPUS:0028968080

SN - 0032-1052

VL - 95

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JO - Plastic and Reconstructive Surgery

JF - Plastic and Reconstructive Surgery

IS - 4

ER -

Iloprost enhances survival of axial-pattern skin flaps in an ischemia-reperfusion model

Abstract

ASJC Scopus subject areas

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