Abstract
The interleukin-1 receptor-associated kinase-1 (IRAK-1) mediates signal transduction from Toll-like/IL-1/IL-18 receptors. Though a critical protective role against Staphylococcus aureus infection has been previously attributed to myeloid differentiation factor 88 (MyD88) and IRAK-4, both also involved in TLR/IL-1/IL-18 signaling, the role of IRAK-1 is unknown. IRAK-1-deficient (IRAK-1 -/-) and wild-type mice were inoculated i.v. with 2 × 10 7 or 1 × 10 6 S. aureus per mouse to evaluate the role of IRAK-1 in S. aureus sepsis. Since IRAK-1 transduces IL-1R signals, IL-1R -/- mice were also included in experiments. IRAK-1 -/- mice are susceptible to a high dose of S. aureus compared to wild-type controls. In contrast to the high mortality and extensive weight loss seen in IL-1R-deficient mice in response to 1 × 10 6 S. aureus, IRAK-1 -/- mice are resistant to this low dose of S. aureus. Thus IRAK-1 plays an important role in the host response to staphylococcal sepsis.
Original language | English (US) |
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Pages (from-to) | 1268-1272 |
Number of pages | 5 |
Journal | Microbes and Infection |
Volume | 6 |
Issue number | 14 |
DOIs | |
State | Published - Nov 2004 |
Keywords
- Bacterial
- Cytokine receptors
- Inflammation
- Signal transduction
- Transgenic/knockout
ASJC Scopus subject areas
- Microbiology
- Immunology
- Infectious Diseases