Abstract
A human orthologue of the Saccharomyces cerevisiae YVH1 protein-tyrosine phosphatase is able to rescue the slow growth defect caused by the disruption of the S. cerevisiae YVH1 gene. The human YVH1 gene is located on chromosome 1q21-q22, which falls in a region amplified in human liposarcomas. The evolutionary conserved COOH-terminal noncatalytic domain of human YVH1 is essential for in vivo function. The cysteine-rich COOH-terminal domain is capable of coordinating 2 mol of zinc/mol of protein, defining it as a novel zinc finger domain. Human YVH1 is the first protein-tyrosine phosphatase that contains and is regulated by a zinc finger domain.
Original language | English (US) |
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Pages (from-to) | 23991-23995 |
Number of pages | 5 |
Journal | Journal of Biological Chemistry |
Volume | 274 |
Issue number | 34 |
DOIs | |
State | Published - Aug 20 1999 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology