Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening

Chemical Compounds

• Dihydroorotate Dehydrogenase Inhibitor 100%
• Dihydroorotate 87%
• Growth Inhibitor 19%
• Antimalarial Agent 17%
• % Inhibition 15%
• Molecular Mechanic 13%
• Pyrimidine 12%
• Binding Energy 11%
• Biosynthesis 11%
• Surface Area 8%

Engineering & Materials Science

• Oxidoreductases 82%
• Parasites 78%
• Screening 50%
• Molecular mechanics 14%
• Biosynthesis 14%
• Binding energy 14%
• Enzymes 10%

Social Sciences

• mechanic 18%
• energy 12%
• drug 12%