Identification of an active site alanine in mevalonate kinase through characterization of a novel mutation in mevalonate kinase deficiency

Medicine & Life Sciences

• mevalonate kinase 100%
• Mevalonate Kinase Deficiency 96%
• Alanine 58%
• Mevalonic Acid 57%
• Catalytic Domain 51%
• Complementary DNA 34%
• Adenosine Triphosphate 33%
• Mutation 32%
• Proteins 21%
• Alleles 21%
• Kinetics 20%
• Threonine 16%
• Enzymes 15%
• Mutant Proteins 15%
• Affinity Chromatography 15%
• Glutathione Transferase 15%
• Glycine 14%
• Polyacrylamide Gel Electrophoresis 13%
• Digestion 13%
• Cultured Cells 12%
• Nucleotides 11%
• Escherichia coli 10%
• Bacteria 9%
• Polymerase Chain Reaction 8%

Chemical Compounds

• Mevalonate 82%
• Alanine 55%
• Mutation 48%
• Protein 17%
• Threonine 9%
• SDS Polyacrylamide Gel Electrophoresis 8%
• Affinity Chromatography 7%
• Glutathione 7%
• Molecular Mass 7%
• Velocity 6%
• Nucleotide 6%
• Purification 5%