TY - JOUR
T1 - Identification of an achaete-scute homolog, Fash1, from Fugu rubripes
AU - Verma-Kurvari, Sunita
AU - Johnson, Jane E.
N1 - Funding Information:
We would like to thank Drs S. Aparicio and S. Brenner (MRC Molecular Genetics Unit and Department of Medicine, Cambridge, UK) for Fugu libraries and Fugu genomic DNA. J.E.J. is an established investigator of the American Heart Association. This work was funded by NIH RO1-NS32817.
PY - 1997/10/24
Y1 - 1997/10/24
N2 - Proteins of the achaete-scute family of transcription factors play important roles in neurogenesis in both invertebrates and vertebrates. Here, we report the cloning and characterization of a Japanese pufferfish, Fugu rubripes achaete-scute homolog 1, Fash1. Sequence alignment of the predicted amino acid sequence of Fash1 with other vertebrate homologs of the achaete-scute homolog 1 subclass shows that the carboxyl 2/3 of the protein, including the basic helix-loop-helix, a putative nuclear localization signal and several consensus phosphorylation sites, is highly conserved. Strikingly, the similarity in this region between eight vertebrate species is close to 90%.
AB - Proteins of the achaete-scute family of transcription factors play important roles in neurogenesis in both invertebrates and vertebrates. Here, we report the cloning and characterization of a Japanese pufferfish, Fugu rubripes achaete-scute homolog 1, Fash1. Sequence alignment of the predicted amino acid sequence of Fash1 with other vertebrate homologs of the achaete-scute homolog 1 subclass shows that the carboxyl 2/3 of the protein, including the basic helix-loop-helix, a putative nuclear localization signal and several consensus phosphorylation sites, is highly conserved. Strikingly, the similarity in this region between eight vertebrate species is close to 90%.
KW - Mash1
KW - Transcription factor
KW - bHLH
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U2 - 10.1016/S0378-1119(97)00394-6
DO - 10.1016/S0378-1119(97)00394-6
M3 - Article
C2 - 9373148
AN - SCOPUS:0030810325
SN - 0378-1119
VL - 200
SP - 145
EP - 148
JO - Gene
JF - Gene
IS - 1-2
ER -