Abstract
A key cytokine Induced during the Immune response is IL-2. Following T cell activation, the genes encoding IL-2 and the various chains of Its receptor are transcriptionally induced. In turn, secreted IL-2 serves to stimulate the proliferation and differentiation of T lymphocytes. Several recent studies have implicated Jak kinasea in the signaling pathway Induced by IL-2. Following this lead, we set out to identify transcription factors Induced In response to IL-2. Human peripheral blood lymphocytes were observed to contain several IL-2-induclbie DNA binding activities. Similar activities were also observed in a transformed human lymphocyte line, termed YT. We have purified these activities and found that the principal IL-2-inducible component bears significant relatedness to a prolactin-induced transcription factor first identified in sheep mammary gland tissue. We hypothesize that activation of this protein, designated hStat5, helps govern the biological effects of IL-2 during the Immune response.
Original language | English (US) |
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Pages (from-to) | 321-329 |
Number of pages | 9 |
Journal | Immunity |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1995 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases