Identification and characterization of β-sitosterol target proteins

Brett Lomenick; Heping Shi; Jing Huang; Chuo Chen

doi:10.1016/j.bmcl.2015.03.007

Identification and characterization of β-sitosterol target proteins

Brett Lomenick, Heping Shi, Jing Huang, Chuo Chen

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

β-Sitosterol is the most abundant plant sterol in the human diet. It is also the major component of several traditional medicines, including saw palmetto and devil's claw. Although β-sitosterol is effective against enlarged prostate in human clinical trials and has anti-cancer and anti-inflammatory activities, the mechanisms of action are poorly understood. Here, we report the identification of two new binding proteins for β-sitosterol that may underlie its beneficial effects.

Original language	English (US)
Pages (from-to)	4976-4979
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	21
DOIs	https://doi.org/10.1016/j.bmcl.2015.03.007
State	Published - Nov 1 2015

Keywords

17β-HSD4
E-Syt1
Phytosterol
Target identification
β-Sitosterol

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2015.03.007

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title = "Identification and characterization of β-sitosterol target proteins",

abstract = "β-Sitosterol is the most abundant plant sterol in the human diet. It is also the major component of several traditional medicines, including saw palmetto and devil's claw. Although β-sitosterol is effective against enlarged prostate in human clinical trials and has anti-cancer and anti-inflammatory activities, the mechanisms of action are poorly understood. Here, we report the identification of two new binding proteins for β-sitosterol that may underlie its beneficial effects.",

keywords = "17β-HSD4, E-Syt1, Phytosterol, Target identification, β-Sitosterol",

author = "Brett Lomenick and Heping Shi and Jing Huang and Chuo Chen",

note = "Funding Information: Support for this research is provided by the NIH National Center for Complementary and Alternative Medicine ( R01-AT006889 to C.C. and J.H.). B.L. is supported by the NIH-UCLA Tumor Immunology Training Program ( T32-CA009120 ). We thank Yi-Pei Chen and Tremylla Johnson for technical assistance. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",

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doi = "10.1016/j.bmcl.2015.03.007",

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AU - Lomenick, Brett

AU - Shi, Heping

AU - Huang, Jing

AU - Chen, Chuo

N1 - Funding Information: Support for this research is provided by the NIH National Center for Complementary and Alternative Medicine ( R01-AT006889 to C.C. and J.H.). B.L. is supported by the NIH-UCLA Tumor Immunology Training Program ( T32-CA009120 ). We thank Yi-Pei Chen and Tremylla Johnson for technical assistance. Publisher Copyright: © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - β-Sitosterol is the most abundant plant sterol in the human diet. It is also the major component of several traditional medicines, including saw palmetto and devil's claw. Although β-sitosterol is effective against enlarged prostate in human clinical trials and has anti-cancer and anti-inflammatory activities, the mechanisms of action are poorly understood. Here, we report the identification of two new binding proteins for β-sitosterol that may underlie its beneficial effects.

AB - β-Sitosterol is the most abundant plant sterol in the human diet. It is also the major component of several traditional medicines, including saw palmetto and devil's claw. Although β-sitosterol is effective against enlarged prostate in human clinical trials and has anti-cancer and anti-inflammatory activities, the mechanisms of action are poorly understood. Here, we report the identification of two new binding proteins for β-sitosterol that may underlie its beneficial effects.

KW - 17β-HSD4

KW - E-Syt1

KW - Phytosterol

KW - Target identification

KW - β-Sitosterol

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JO - Bioorganic and Medicinal Chemistry Letters

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Identification and characterization of β-sitosterol target proteins

Abstract

Keywords

ASJC Scopus subject areas

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