TY - JOUR
T1 - Hypoadiponectinemia, dyslipidemia, and impaired growth in children with HIV-associated facial lipoatrophy
AU - Kim, Roy J.
AU - Carlow, Dean C.
AU - Rutstein, Jessica H.
AU - Rutstein, Richard M.
N1 - Funding Information:
This research was partially supported by University of Pennsylvania Center for AIDS Research, NIH IP30AI5008-01 (RR), Johns Hopkins HIV Treatment Network AHCPR 290-98-0016 (RR), and the General Clinical Research Center of the Children's Hospital of Philadelphia, #M01-RR 00240. RK has received support from Genentech. RR has served as a scientific advisor for Abbott and received grant support from Boehringer Ingelheim.
PY - 2007/1
Y1 - 2007/1
N2 - Objective: To compare growth, lipids and adipocytokines in HIV-positive children with and without lipoatrophy. Patients: Eleven HIV-positive children with facial lipoatrophy, and 22 age- and sex-matched HIV-positive controls without signs of fat abnormality. Methods: Clinical data including height, physical examination findings, medications, markers of viral control, cholesterol, and triglycerides were retrieved from the medical charts. Serum samples were analyzed for adiponectin, inflammatory markers, and high density lipoprotein cholesterol (HDL). Results: Lipoatrophy was associated with higher triglycerides (330 vs 133 mg/dl, p = 0.0003), lower HDL (33 vs 48 mg/dl, p = 0.02), and a greater frequency of hypercholesterolemia (total cholesterol >200 mg /dl; 64% vs 23%, p <0.03). Adiponectin was 53% lower in patients with lipodystrophy (6.9 μg/ml vs 14.8 μg/ml, p = 0.005), however there was no difference in the inflammatory markers soluble TNFα receptor 2 or interleukin 6. Strikingly, despite similar BMI z-scores and virological control, lipoatrophic patients were shorter by 1 standard deviation score (p = 0.03). Conclusions: The presence of facial lipoatrophy in a child with HIV infection is a marker for significant metabolic derangements including dyslipidemia and hypoadiponectinemia, and suggests the need for careful growth evaluation.
AB - Objective: To compare growth, lipids and adipocytokines in HIV-positive children with and without lipoatrophy. Patients: Eleven HIV-positive children with facial lipoatrophy, and 22 age- and sex-matched HIV-positive controls without signs of fat abnormality. Methods: Clinical data including height, physical examination findings, medications, markers of viral control, cholesterol, and triglycerides were retrieved from the medical charts. Serum samples were analyzed for adiponectin, inflammatory markers, and high density lipoprotein cholesterol (HDL). Results: Lipoatrophy was associated with higher triglycerides (330 vs 133 mg/dl, p = 0.0003), lower HDL (33 vs 48 mg/dl, p = 0.02), and a greater frequency of hypercholesterolemia (total cholesterol >200 mg /dl; 64% vs 23%, p <0.03). Adiponectin was 53% lower in patients with lipodystrophy (6.9 μg/ml vs 14.8 μg/ml, p = 0.005), however there was no difference in the inflammatory markers soluble TNFα receptor 2 or interleukin 6. Strikingly, despite similar BMI z-scores and virological control, lipoatrophic patients were shorter by 1 standard deviation score (p = 0.03). Conclusions: The presence of facial lipoatrophy in a child with HIV infection is a marker for significant metabolic derangements including dyslipidemia and hypoadiponectinemia, and suggests the need for careful growth evaluation.
KW - Adiponectin
KW - Child
KW - Growth
KW - HIV
KW - Lipids
KW - Lipoatrophy
KW - Lipodystrophy
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U2 - 10.1515/JPEM.2007.20.1.65
DO - 10.1515/JPEM.2007.20.1.65
M3 - Article
C2 - 17315531
AN - SCOPUS:34047265158
SN - 0334-018X
VL - 20
SP - 65
EP - 74
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
IS - 1
ER -