TY - JOUR
T1 - Hyperthermia does not alter the increase in cerebral perfusion during cognitive activation
AU - Schlader, Zachary J.
AU - Lucas, Rebekah A I
AU - Pearson, James
AU - Crandall, Craig G.
PY - 2013/11
Y1 - 2013/11
N2 - This study tested the hypothesis that hyperthermia attenuates the increase in cerebral perfusion during cognitive activation. Mean middle cerebral artery blood velocity (MCAVmean) served as an index of cerebral perfusion, while the nBack test (a test of working memory) was the cognitive task. Hyperthermia was characterized by elevations (P < 0.001) in skin (by 5.0 ± 0.8°C) and intestinal temperatures (by 1.3 ± 0.1°C) and reductions (P < 0.020) in mean arterial pressure (by 11 ± 10 mmHg), end-tidal CO2 tension (by 3 ± 6 mmHg) and MCAVmean (by 10 ± 9 cm s-1). Hyperthermia had no influence on nBack test performance (mean difference from normothermia to hyperthermia, -1 ± 11%; P= 0.276) or, counter to the hypothesis, the increase in MCAVmean during nBack testing (mean difference from normothermia to hyperthermia: 0 ± 16 cm s-1; P= 0.608). These findings indicate that the capacity to increase cerebral perfusion during cognitive activation is unaffected by hyperthermia.
AB - This study tested the hypothesis that hyperthermia attenuates the increase in cerebral perfusion during cognitive activation. Mean middle cerebral artery blood velocity (MCAVmean) served as an index of cerebral perfusion, while the nBack test (a test of working memory) was the cognitive task. Hyperthermia was characterized by elevations (P < 0.001) in skin (by 5.0 ± 0.8°C) and intestinal temperatures (by 1.3 ± 0.1°C) and reductions (P < 0.020) in mean arterial pressure (by 11 ± 10 mmHg), end-tidal CO2 tension (by 3 ± 6 mmHg) and MCAVmean (by 10 ± 9 cm s-1). Hyperthermia had no influence on nBack test performance (mean difference from normothermia to hyperthermia, -1 ± 11%; P= 0.276) or, counter to the hypothesis, the increase in MCAVmean during nBack testing (mean difference from normothermia to hyperthermia: 0 ± 16 cm s-1; P= 0.608). These findings indicate that the capacity to increase cerebral perfusion during cognitive activation is unaffected by hyperthermia.
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U2 - 10.1113/expphysiol.2013.074104
DO - 10.1113/expphysiol.2013.074104
M3 - Article
C2 - 23851918
AN - SCOPUS:84885954588
SN - 0958-0670
VL - 98
SP - 1597
EP - 1607
JO - Experimental Physiology
JF - Experimental Physiology
IS - 11
ER -